Polymorphism in Sp1 recognition site of the EGF receptor gene promoter and risk of glioblastoma

C. Carpentier; F. Laigle-Donadey; Y. Marie; N. Auger; A. Benouaich-Amiel; J. Lejeune; G. Kaloshi; J. Y. Delattre; J. Thillet; M. Sanson

doi:10.1212/01.wnl.0000229927.12007.37

Polymorphism in Sp1 recognition site of the EGF receptor gene promoter and risk of glioblastoma

C. Carpentier, F. Laigle-Donadey, Y. Marie, N. Auger, A. Benouaich-Amiel, J. Lejeune, G. Kaloshi, J. Y. Delattre, J. Thillet, M. Sanson

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Résumé

We investigated two polymorphisms of the epidermal growth factor receptor promoter as potential risk factors and prognostic markers for glioblastoma. The -216T allele (which results in a 30% higher activity) was more frequent in the patients compared with the control population (224/376 = 59.6% vs 165/352 = 46.8%; p = 0.0006) corresponding to an odd ratio of 1.67 (1.24; 2.25). A modest difference in median survival was also associated with the TT genotype.

langue originale	Anglais
Pages (de - à)	872-874
Nombre de pages	3
journal	Neurology
Volume	67
Numéro de publication	5
Les DOIs	https://doi.org/10.1212/01.wnl.0000229927.12007.37
état	Publié - 1 janv. 2006
Modification externe	Oui

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10.1212/01.wnl.0000229927.12007.37

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abstract = "We investigated two polymorphisms of the epidermal growth factor receptor promoter as potential risk factors and prognostic markers for glioblastoma. The -216T allele (which results in a 30% higher activity) was more frequent in the patients compared with the control population (224/376 = 59.6% vs 165/352 = 46.8%; p = 0.0006) corresponding to an odd ratio of 1.67 (1.24; 2.25). A modest difference in median survival was also associated with the TT genotype.",

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AU - Carpentier, C.

AU - Laigle-Donadey, F.

AU - Marie, Y.

AU - Auger, N.

AU - Benouaich-Amiel, A.

AU - Lejeune, J.

AU - Kaloshi, G.

AU - Delattre, J. Y.

AU - Thillet, J.

AU - Sanson, M.

PY - 2006/1/1

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N2 - We investigated two polymorphisms of the epidermal growth factor receptor promoter as potential risk factors and prognostic markers for glioblastoma. The -216T allele (which results in a 30% higher activity) was more frequent in the patients compared with the control population (224/376 = 59.6% vs 165/352 = 46.8%; p = 0.0006) corresponding to an odd ratio of 1.67 (1.24; 2.25). A modest difference in median survival was also associated with the TT genotype.

AB - We investigated two polymorphisms of the epidermal growth factor receptor promoter as potential risk factors and prognostic markers for glioblastoma. The -216T allele (which results in a 30% higher activity) was more frequent in the patients compared with the control population (224/376 = 59.6% vs 165/352 = 46.8%; p = 0.0006) corresponding to an odd ratio of 1.67 (1.24; 2.25). A modest difference in median survival was also associated with the TT genotype.

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