TY - JOUR
T1 - Pooled Systemic Efficacy and Safety Data from the Pivotal Phase II Studies (NP28673 and NP28761) of Alectinib in ALK-positive Non-Small Cell Lung Cancer
AU - Yang, James Chih Hsin
AU - Ou, Sai Hong Ignatius
AU - De Petris, Luigi
AU - Gadgeel, Shirish
AU - Gandhi, Leena
AU - Kim, Dong Wan
AU - Barlesi, Fabrice
AU - Govindan, Ramaswamy
AU - Dingemans, Anne Marie C.
AU - Crino, Lucio
AU - Lena, Herve
AU - Popat, Sanjay
AU - Ahn, Jin Seok
AU - Dansin, Eric
AU - Golding, Sophie
AU - Bordogna, Walter
AU - Balas, Bogdana
AU - Morcos, Peter N.
AU - Zeaiter, Ali
AU - Shaw, Alice T.
N1 - Publisher Copyright:
© 2017 International Association for the Study of Lung Cancer
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Introduction Alectinib demonstrated clinical efficacy and an acceptable safety profile in two phase II studies (NP28761 and NP28673). Here we report the pooled efficacy and safety data after 15 and 18 months more follow-up than in the respective primary analyses. Methods Enrolled patients had ALK receptor tyrosine kinase gene (ALK)-positive NSCLC and had progressed while taking, or could not tolerate, crizotinib. Patients received oral alectinib, 600 mg twice daily. The primary end point in both studies was objective response rate assessed by an independent review committee (IRC) using the Response Evaluation Criteria in Solid Tumors, version 1.1. Secondary end points included disease control rate, duration of response, progression-free survival, overall survival, and safety. Results The pooled data set included 225 patients (n = 138 in NP28673 and n = 87 in NP28761). The response-evaluable population included 189 patients (84% [n = 122 in NP28673 and n = 67 in NP28761]). In the response-evaluable population, objective response rate as assessed by the IRC was 51.3% (95% confidence interval [CI]: 44.0–58.6 [all PRs]), the disease control rate was 78.8% (95% CI: 72.3–84.4), and the median duration of response was 14.9 months (95% CI: 11.1–20.4) after 58% of events. Median progression-free survival as assessed by the IRC was 8.3 months (95% CI: 7.0–11.3) and median overall survival was 26.0 months (95% CI: 21.4–not estimable). Grade 3 or higher adverse events (AEs) occurred in 40% of patients, 6% of patients had treatment withdrawn on account of AEs, and 33% had AEs leading to dose interruptions/modification. Conclusions This pooled data analysis confirmed the robust systemic efficacy of alectinib in ALK-positive NSCLC with a durable response rate. Alectinib also had an acceptable safety profile with a longer duration of follow-up.
AB - Introduction Alectinib demonstrated clinical efficacy and an acceptable safety profile in two phase II studies (NP28761 and NP28673). Here we report the pooled efficacy and safety data after 15 and 18 months more follow-up than in the respective primary analyses. Methods Enrolled patients had ALK receptor tyrosine kinase gene (ALK)-positive NSCLC and had progressed while taking, or could not tolerate, crizotinib. Patients received oral alectinib, 600 mg twice daily. The primary end point in both studies was objective response rate assessed by an independent review committee (IRC) using the Response Evaluation Criteria in Solid Tumors, version 1.1. Secondary end points included disease control rate, duration of response, progression-free survival, overall survival, and safety. Results The pooled data set included 225 patients (n = 138 in NP28673 and n = 87 in NP28761). The response-evaluable population included 189 patients (84% [n = 122 in NP28673 and n = 67 in NP28761]). In the response-evaluable population, objective response rate as assessed by the IRC was 51.3% (95% confidence interval [CI]: 44.0–58.6 [all PRs]), the disease control rate was 78.8% (95% CI: 72.3–84.4), and the median duration of response was 14.9 months (95% CI: 11.1–20.4) after 58% of events. Median progression-free survival as assessed by the IRC was 8.3 months (95% CI: 7.0–11.3) and median overall survival was 26.0 months (95% CI: 21.4–not estimable). Grade 3 or higher adverse events (AEs) occurred in 40% of patients, 6% of patients had treatment withdrawn on account of AEs, and 33% had AEs leading to dose interruptions/modification. Conclusions This pooled data analysis confirmed the robust systemic efficacy of alectinib in ALK-positive NSCLC with a durable response rate. Alectinib also had an acceptable safety profile with a longer duration of follow-up.
KW - Alectinib
KW - NP28673
KW - NP28761
KW - Non–small cell lung cancer
KW - Pooled analysis
UR - http://www.scopus.com/inward/record.url?scp=85026842275&partnerID=8YFLogxK
U2 - 10.1016/j.jtho.2017.06.070
DO - 10.1016/j.jtho.2017.06.070
M3 - Article
C2 - 28689043
AN - SCOPUS:85026842275
SN - 1556-0864
VL - 12
SP - 1552
EP - 1560
JO - Journal of Thoracic Oncology
JF - Journal of Thoracic Oncology
IS - 10
ER -