TY - JOUR
T1 - Portal vein thrombosis during antineoplastic chemotherapy in children
T2 - Report of five cases and review of the literature
AU - Brisse, H.
AU - Orbach, D.
AU - Lassau, N.
AU - Servois, V.
AU - Doz, F.
AU - Debray, D.
AU - Helfre, S.
AU - Hartmann, O.
AU - Neuenschwander, S.
PY - 2004/1/1
Y1 - 2004/1/1
N2 - We report five paediatric cases of portal vein thrombosis (PVT) occurring during chemotherapy, observed in two institutions over an 8-year time period. These children aged 2.5-15 years were treated for Burkitt's lymphoma, Ewing's tumour, small cell bone tumour or medulloblastoma. PVT was diagnosed on colour Doppler ultrasonography (US). In four patients, thrombosis occurred 2-45 days after severe hepatic veno-occlusive disease (HVOD) secondary to intensive chemotherapy containing busulfan. In one case, PVT occurred in the absence of HVOD in a patient with pre-existing periportal lymphomatous infiltration. Four patients experienced persistent portal hypertension, which resulted in death in one. PVT during chemotherapy in children is a rare event and appears to be closely related to intensive chemotherapy containing busulfan and to be associated with HVOD.
AB - We report five paediatric cases of portal vein thrombosis (PVT) occurring during chemotherapy, observed in two institutions over an 8-year time period. These children aged 2.5-15 years were treated for Burkitt's lymphoma, Ewing's tumour, small cell bone tumour or medulloblastoma. PVT was diagnosed on colour Doppler ultrasonography (US). In four patients, thrombosis occurred 2-45 days after severe hepatic veno-occlusive disease (HVOD) secondary to intensive chemotherapy containing busulfan. In one case, PVT occurred in the absence of HVOD in a patient with pre-existing periportal lymphomatous infiltration. Four patients experienced persistent portal hypertension, which resulted in death in one. PVT during chemotherapy in children is a rare event and appears to be closely related to intensive chemotherapy containing busulfan and to be associated with HVOD.
KW - Alkylating agents
KW - Antineoplastic agents
KW - Child
KW - Haematopoietic cell transplantation
KW - Hepatic veno-occlusive disease
KW - Liver
KW - Portal vein
KW - Thromboembolism
KW - Ultrasonography
UR - http://www.scopus.com/inward/record.url?scp=9644259086&partnerID=8YFLogxK
U2 - 10.1016/j.ejca.2004.06.013
DO - 10.1016/j.ejca.2004.06.013
M3 - Article
AN - SCOPUS:9644259086
SN - 0959-8049
VL - 40
SP - 2659
EP - 2666
JO - European Journal of Cancer
JF - European Journal of Cancer
IS - 18
ER -