Precision oncology: Indications and challenges in the implementation of high-throughput sequencing in clinical practice

Arianna Marinello, Mihaela Aldea

    Résultats de recherche: Le chapitre dans un livre, un rapport, une anthologie ou une collection!!ChapterRevue par des pairs

    Résumé

    Precision medicine has become essential in oncology patient care, largely due to advances in high-throughput sequencing techniques, particularly next-generation sequencing (NGS). NGS enables a range of clinical applications, including targeted treatment selection, identification of resistance mechanisms, detection of germline mutations and occult malignancies, and evaluation of minimal residual disease. These applications are typically assessed during molecular tumor board discussions, where a multidisciplinary team evaluates the actionability of identified molecular alterations. Despite significant progress, challenges such as limited clinician education, high costs, and restricted drug availability continue to hinder widespread clinical implementation. Looking forward, the integration of machine learning and genomics into larger datasets holds the potential to deepen our understanding, providing more comprehensive multiomic data for future advancements in precision oncology.

    langue originaleAnglais
    titreImplementation of Personalized Precision Medicine
    Sous-titreExpanding the Clinical Vision towards Prevention, Early Detection and Precision Treatment of Disease to Drive Extended Healthspan
    EditeurElsevier
    Pages203-221
    Nombre de pages19
    ISBN (Electronique)9780323988087
    ISBN (imprimé)9780323972765
    Les DOIs
    étatPublié - 1 janv. 2024

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