Résumé
Precision medicine has become essential in oncology patient care, largely due to advances in high-throughput sequencing techniques, particularly next-generation sequencing (NGS). NGS enables a range of clinical applications, including targeted treatment selection, identification of resistance mechanisms, detection of germline mutations and occult malignancies, and evaluation of minimal residual disease. These applications are typically assessed during molecular tumor board discussions, where a multidisciplinary team evaluates the actionability of identified molecular alterations. Despite significant progress, challenges such as limited clinician education, high costs, and restricted drug availability continue to hinder widespread clinical implementation. Looking forward, the integration of machine learning and genomics into larger datasets holds the potential to deepen our understanding, providing more comprehensive multiomic data for future advancements in precision oncology.
langue originale | Anglais |
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titre | Implementation of Personalized Precision Medicine |
Sous-titre | Expanding the Clinical Vision towards Prevention, Early Detection and Precision Treatment of Disease to Drive Extended Healthspan |
Editeur | Elsevier |
Pages | 203-221 |
Nombre de pages | 19 |
ISBN (Electronique) | 9780323988087 |
ISBN (imprimé) | 9780323972765 |
Les DOIs | |
état | Publié - 1 janv. 2024 |