TY - JOUR
T1 - Precision oncology
T2 - Separating the wheat from the chaff
AU - Remon, Jordi
AU - Dienstmann, Rodrigo
N1 - Publisher Copyright:
© Author (s) (or their employer(s)) 2018.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Precision oncology based on next-generation sequencing (NGS) test is growing in daily clinical practice. However, the real impact of this strategy in patients' outcome on a large scale remains uncertain. In this review, we summarise existing literature on this topic, limitations for broad NGS implementation, bottlenecks in genomic variant interpretation and the role of molecular tumour boards.
AB - Precision oncology based on next-generation sequencing (NGS) test is growing in daily clinical practice. However, the real impact of this strategy in patients' outcome on a large scale remains uncertain. In this review, we summarise existing literature on this topic, limitations for broad NGS implementation, bottlenecks in genomic variant interpretation and the role of molecular tumour boards.
KW - next-generation sequencing
KW - oncogenic-addicted tumors
KW - personalized medicine
UR - http://www.scopus.com/inward/record.url?scp=85056230924&partnerID=8YFLogxK
U2 - 10.1136/esmoopen-2018-000446
DO - 10.1136/esmoopen-2018-000446
M3 - Review article
AN - SCOPUS:85056230924
SN - 2059-7029
VL - 3
JO - ESMO Open
JF - ESMO Open
IS - 6
M1 - e000446
ER -