Prevalence and characteristics of HPV-driven oropharyngeal cancer in France

Haitham Mirghani; Carine Bellera; Jessy Delaye; Gilles Dolivet; Nicolas Fakhry; Alexandre Bozec; Renaud Garrel; Olivier Malard; Franck Jegoux; Philippe Maingon; Jérome Sarini; Georges Noel; Suzy Duflo; Stéphane Temam; Jean louis Lefebvre; Valérie Costes-Martineau

doi:10.1016/j.canep.2019.05.007

Prevalence and characteristics of HPV-driven oropharyngeal cancer in France

Haitham Mirghani, Carine Bellera, Jessy Delaye, Gilles Dolivet, Nicolas Fakhry, Alexandre Bozec, Renaud Garrel, Olivier Malard, Franck Jegoux, Philippe Maingon, Jérome Sarini, Georges Noel, Suzy Duflo, Stéphane Temam, Jean louis Lefebvre, Valérie Costes-Martineau

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

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Résumé

Background: France has one of the highest incidence of head and neck cancers in Europe. Despite this, the epidemiological impact of high-risk human papilloma virus (HR-HPV)remains poorly investigated. Methods: We prospective assessed the proportion of oropharyngeal cancers due to HR-HPV in 15 hospitals throughout France. HPV-status was determined by p16-immunohistochemistry, and by detection of HPV-DNA using in situ hybridization. Cancers were classified as HPV-driven if both p16-immunohistochemistry and HPV-DNA assays were positive. Demographical and clinical features were recorded. Results: 291 patients with palatine-tonsil or tongue-base cancers were recruited from March-2011 to July-2012. Of these, 43.1% of samples were p16-positive and 37.7% were positive for both p16 and HPV-DNA. Prognosis was significantly better in patients with HPV-driven cancers, with smoking negatively impacting patients’ oncological outcomes. Conclusion: In France, more than a third of tonsillar and tongue base cancers are HPV-driven. More research concerning the evolution of HPV-driven cancers over time is needed.

langue originale	Anglais
Pages (de - à)	89-94
Nombre de pages	6
journal	Cancer Epidemiology
Volume	61
Les DOIs	https://doi.org/10.1016/j.canep.2019.05.007
état	Publié - 1 août 2019

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10.1016/j.canep.2019.05.007

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@article{13e678d5266b4b9294af540fef77704c,

title = "Prevalence and characteristics of HPV-driven oropharyngeal cancer in France",

abstract = "Background: France has one of the highest incidence of head and neck cancers in Europe. Despite this, the epidemiological impact of high-risk human papilloma virus (HR-HPV)remains poorly investigated. Methods: We prospective assessed the proportion of oropharyngeal cancers due to HR-HPV in 15 hospitals throughout France. HPV-status was determined by p16-immunohistochemistry, and by detection of HPV-DNA using in situ hybridization. Cancers were classified as HPV-driven if both p16-immunohistochemistry and HPV-DNA assays were positive. Demographical and clinical features were recorded. Results: 291 patients with palatine-tonsil or tongue-base cancers were recruited from March-2011 to July-2012. Of these, 43.1% of samples were p16-positive and 37.7% were positive for both p16 and HPV-DNA. Prognosis was significantly better in patients with HPV-driven cancers, with smoking negatively impacting patients{\textquoteright} oncological outcomes. Conclusion: In France, more than a third of tonsillar and tongue base cancers are HPV-driven. More research concerning the evolution of HPV-driven cancers over time is needed.",

keywords = "cancer(s), epidemiology, France, Human papillomavirus (HPV), neoplasm(s), oral/oropharynx/oropharyngeal, prevalence, tonsil/tonsillar",

author = "Haitham Mirghani and Carine Bellera and Jessy Delaye and Gilles Dolivet and Nicolas Fakhry and Alexandre Bozec and Renaud Garrel and Olivier Malard and Franck Jegoux and Philippe Maingon and J{\'e}rome Sarini and Georges Noel and Suzy Duflo and St{\'e}phane Temam and Lefebvre, {Jean louis} and Val{\'e}rie Costes-Martineau",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = aug,

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doi = "10.1016/j.canep.2019.05.007",

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TY - JOUR

T1 - Prevalence and characteristics of HPV-driven oropharyngeal cancer in France

AU - Mirghani, Haitham

AU - Bellera, Carine

AU - Delaye, Jessy

AU - Dolivet, Gilles

AU - Fakhry, Nicolas

AU - Bozec, Alexandre

AU - Garrel, Renaud

AU - Malard, Olivier

AU - Jegoux, Franck

AU - Maingon, Philippe

AU - Sarini, Jérome

AU - Noel, Georges

AU - Duflo, Suzy

AU - Temam, Stéphane

AU - Lefebvre, Jean louis

AU - Costes-Martineau, Valérie

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Background: France has one of the highest incidence of head and neck cancers in Europe. Despite this, the epidemiological impact of high-risk human papilloma virus (HR-HPV)remains poorly investigated. Methods: We prospective assessed the proportion of oropharyngeal cancers due to HR-HPV in 15 hospitals throughout France. HPV-status was determined by p16-immunohistochemistry, and by detection of HPV-DNA using in situ hybridization. Cancers were classified as HPV-driven if both p16-immunohistochemistry and HPV-DNA assays were positive. Demographical and clinical features were recorded. Results: 291 patients with palatine-tonsil or tongue-base cancers were recruited from March-2011 to July-2012. Of these, 43.1% of samples were p16-positive and 37.7% were positive for both p16 and HPV-DNA. Prognosis was significantly better in patients with HPV-driven cancers, with smoking negatively impacting patients’ oncological outcomes. Conclusion: In France, more than a third of tonsillar and tongue base cancers are HPV-driven. More research concerning the evolution of HPV-driven cancers over time is needed.

AB - Background: France has one of the highest incidence of head and neck cancers in Europe. Despite this, the epidemiological impact of high-risk human papilloma virus (HR-HPV)remains poorly investigated. Methods: We prospective assessed the proportion of oropharyngeal cancers due to HR-HPV in 15 hospitals throughout France. HPV-status was determined by p16-immunohistochemistry, and by detection of HPV-DNA using in situ hybridization. Cancers were classified as HPV-driven if both p16-immunohistochemistry and HPV-DNA assays were positive. Demographical and clinical features were recorded. Results: 291 patients with palatine-tonsil or tongue-base cancers were recruited from March-2011 to July-2012. Of these, 43.1% of samples were p16-positive and 37.7% were positive for both p16 and HPV-DNA. Prognosis was significantly better in patients with HPV-driven cancers, with smoking negatively impacting patients’ oncological outcomes. Conclusion: In France, more than a third of tonsillar and tongue base cancers are HPV-driven. More research concerning the evolution of HPV-driven cancers over time is needed.

KW - cancer(s)

KW - epidemiology

KW - France

KW - Human papillomavirus (HPV)

KW - neoplasm(s)

KW - oral/oropharynx/oropharyngeal

KW - prevalence

KW - tonsil/tonsillar

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DO - 10.1016/j.canep.2019.05.007

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SN - 1877-7821

VL - 61

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JO - Cancer Epidemiology

JF - Cancer Epidemiology

ER -