Primary mediastinal B-cell lymphoma (PMBCL): The LYSA pragmatic guidelines

Loïc Renaud; Marie Donzel; Justine Decroocq; Pierre Decazes; Jean Galtier; Barbara Burroni; Elena Liana Veresezan; Côme Sesboüé; Peggy Dartigues; Catherine Chassagne-Clément; Laurent Martin; Claire Mauduit; Sophie Kaltenbach; Dominique Penther; Pascaline Etancelin; David Sibon; Sarah Bailly; Valentine Martin; Eric Durot; Youlia Kirova; Adrien Grenier; Marie Maerevoet; Wivine Bernard; Louise Naveau; Aurélie Cabannes-Hamy; Anne Ségolène Cottereau; Nicolas Jacquet-Francillon; Robin Noel; Thibaut Reichert; Clémentine Sarkozy; Lucile Bussot; Sébastien Bailly; Sandy Amorim; Daphné Krzisch; Jérôme Cornillon; Hugo Legendre; Florian Chevillon; Doriane Cavalieri; Pierre Sesques; Véronique Minard-Colin; Corinne Haioun; Franck Morschhauser; Roch Houot; Fabrice Jardin; Hervé Tilly; Alexandra Traverse-Glehen; Vincent Camus

doi:10.1016/j.ejca.2025.115369

Primary mediastinal B-cell lymphoma (PMBCL): The LYSA pragmatic guidelines

Loïc Renaud, Marie Donzel, Justine Decroocq, Pierre Decazes, Jean Galtier, Barbara Burroni, Elena Liana Veresezan, Côme Sesboüé, Peggy Dartigues, Catherine Chassagne-Clément, Laurent Martin, Claire Mauduit, Sophie Kaltenbach, Dominique Penther, Pascaline Etancelin, David Sibon, Sarah Bailly, Valentine Martin, Eric Durot, Youlia KirovaAdrien Grenier, Marie Maerevoet, Wivine Bernard, Louise Naveau, Aurélie Cabannes-Hamy, Anne Ségolène Cottereau, Nicolas Jacquet-Francillon, Robin Noel, Thibaut Reichert, Clémentine Sarkozy, Lucile Bussot, Sébastien Bailly, Sandy Amorim, Daphné Krzisch, Jérôme Cornillon, Hugo Legendre, Florian Chevillon, Doriane Cavalieri, Pierre Sesques, Véronique Minard-Colin, Corinne Haioun, Franck Morschhauser, Roch Houot, Fabrice Jardin, Hervé Tilly, Alexandra Traverse-Glehen, Vincent Camus

Résultats de recherche: Contribution à un journal › Article 'review' › Revue par des pairs

Résumé

Primary mediastinal B-cell lymphoma (PMBCL) is a distinct subtype of large B-cell lymphoma with unique clinical, histopathological, and molecular characteristics. Despite its aggressive nature, PMBCL has a high cure rate when managed appropriately. Advances in the understanding of PMBCL biological characteristics, coupled with improvements in diagnostic tools and therapeutic approaches, have significantly improved patient outcomes in recent years. In this article, we present a set of pragmatic guidelines developed by the Lymphoma Study Association (LYSA) for the management of PMBCL. These guidelines address key aspects of diagnosis, staging, response evaluation, and treatment, integrating the latest evidence from clinical trials, expert consensus, and real-world practice. The aim of the guidelines is to provide clinicians with a clear, practical framework to optimize care for patients with PMBCL, ensuring that the best available evidence is translated into clinical practice.

langue originale	Anglais
Numéro d'article	115369
journal	European Journal of Cancer
Volume	220
Les DOIs	https://doi.org/10.1016/j.ejca.2025.115369
état	Publié - 2 mai 2025

Accès au document

10.1016/j.ejca.2025.115369

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Renaud, L., Donzel, M., Decroocq, J., Decazes, P., Galtier, J., Burroni, B., Veresezan, E. L., Sesboüé, C., Dartigues, P., Chassagne-Clément, C., Martin, L., Mauduit, C., Kaltenbach, S., Penther, D., Etancelin, P., Sibon, D., Bailly, S., Martin, V., Durot, E., ... Camus, V. (2025). Primary mediastinal B-cell lymphoma (PMBCL): The LYSA pragmatic guidelines. European Journal of Cancer, 220, Article 115369. https://doi.org/10.1016/j.ejca.2025.115369

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title = "Primary mediastinal B-cell lymphoma (PMBCL): The LYSA pragmatic guidelines",

abstract = "Primary mediastinal B-cell lymphoma (PMBCL) is a distinct subtype of large B-cell lymphoma with unique clinical, histopathological, and molecular characteristics. Despite its aggressive nature, PMBCL has a high cure rate when managed appropriately. Advances in the understanding of PMBCL biological characteristics, coupled with improvements in diagnostic tools and therapeutic approaches, have significantly improved patient outcomes in recent years. In this article, we present a set of pragmatic guidelines developed by the Lymphoma Study Association (LYSA) for the management of PMBCL. These guidelines address key aspects of diagnosis, staging, response evaluation, and treatment, integrating the latest evidence from clinical trials, expert consensus, and real-world practice. The aim of the guidelines is to provide clinicians with a clear, practical framework to optimize care for patients with PMBCL, ensuring that the best available evidence is translated into clinical practice.",

keywords = "Guidelines, LYSA, Primary mediastinal B-cell lymphoma",

author = "Lo{\"i}c Renaud and Marie Donzel and Justine Decroocq and Pierre Decazes and Jean Galtier and Barbara Burroni and Veresezan, {Elena Liana} and C{\^o}me Sesbo{\"u}{\'e} and Peggy Dartigues and Catherine Chassagne-Cl{\'e}ment and Laurent Martin and Claire Mauduit and Sophie Kaltenbach and Dominique Penther and Pascaline Etancelin and David Sibon and Sarah Bailly and Valentine Martin and Eric Durot and Youlia Kirova and Adrien Grenier and Marie Maerevoet and Wivine Bernard and Louise Naveau and Aur{\'e}lie Cabannes-Hamy and Cottereau, {Anne S{\'e}gol{\`e}ne} and Nicolas Jacquet-Francillon and Robin Noel and Thibaut Reichert and Cl{\'e}mentine Sarkozy and Lucile Bussot and S{\'e}bastien Bailly and Sandy Amorim and Daphn{\'e} Krzisch and J{\'e}r{\^o}me Cornillon and Hugo Legendre and Florian Chevillon and Doriane Cavalieri and Pierre Sesques and V{\'e}ronique Minard-Colin and Corinne Haioun and Franck Morschhauser and Roch Houot and Fabrice Jardin and Herv{\'e} Tilly and Alexandra Traverse-Glehen and Vincent Camus",

note = "Publisher Copyright: {\textcopyright} 2025 The Authors",

year = "2025",

month = may,

day = "2",

doi = "10.1016/j.ejca.2025.115369",

language = "English",

volume = "220",

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Renaud, L, Donzel, M, Decroocq, J, Decazes, P, Galtier, J, Burroni, B, Veresezan, EL, Sesboüé, C, Dartigues, P, Chassagne-Clément, C, Martin, L, Mauduit, C, Kaltenbach, S, Penther, D, Etancelin, P, Sibon, D, Bailly, S, Martin, V, Durot, E, Kirova, Y, Grenier, A, Maerevoet, M, Bernard, W, Naveau, L, Cabannes-Hamy, A, Cottereau, AS, Jacquet-Francillon, N, Noel, R, Reichert, T, Sarkozy, C, Bussot, L, Bailly, S, Amorim, S, Krzisch, D, Cornillon, J, Legendre, H, Chevillon, F, Cavalieri, D, Sesques, P, Minard-Colin, V, Haioun, C, Morschhauser, F, Houot, R, Jardin, F, Tilly, H, Traverse-Glehen, A & Camus, V 2025, 'Primary mediastinal B-cell lymphoma (PMBCL): The LYSA pragmatic guidelines', European Journal of Cancer, VOL. 220, 115369. https://doi.org/10.1016/j.ejca.2025.115369

TY - JOUR

T1 - Primary mediastinal B-cell lymphoma (PMBCL)

T2 - The LYSA pragmatic guidelines

AU - Renaud, Loïc

AU - Donzel, Marie

AU - Decroocq, Justine

AU - Decazes, Pierre

AU - Galtier, Jean

AU - Burroni, Barbara

AU - Veresezan, Elena Liana

AU - Sesboüé, Côme

AU - Dartigues, Peggy

AU - Chassagne-Clément, Catherine

AU - Martin, Laurent

AU - Mauduit, Claire

AU - Kaltenbach, Sophie

AU - Penther, Dominique

AU - Etancelin, Pascaline

AU - Sibon, David

AU - Bailly, Sarah

AU - Martin, Valentine

AU - Durot, Eric

AU - Kirova, Youlia

AU - Grenier, Adrien

AU - Maerevoet, Marie

AU - Bernard, Wivine

AU - Naveau, Louise

AU - Cabannes-Hamy, Aurélie

AU - Cottereau, Anne Ségolène

AU - Jacquet-Francillon, Nicolas

AU - Noel, Robin

AU - Reichert, Thibaut

AU - Sarkozy, Clémentine

AU - Bussot, Lucile

AU - Bailly, Sébastien

AU - Amorim, Sandy

AU - Krzisch, Daphné

AU - Cornillon, Jérôme

AU - Legendre, Hugo

AU - Chevillon, Florian

AU - Cavalieri, Doriane

AU - Sesques, Pierre

AU - Minard-Colin, Véronique

AU - Haioun, Corinne

AU - Morschhauser, Franck

AU - Houot, Roch

AU - Jardin, Fabrice

AU - Tilly, Hervé

AU - Traverse-Glehen, Alexandra

AU - Camus, Vincent

PY - 2025/5/2

Y1 - 2025/5/2

N2 - Primary mediastinal B-cell lymphoma (PMBCL) is a distinct subtype of large B-cell lymphoma with unique clinical, histopathological, and molecular characteristics. Despite its aggressive nature, PMBCL has a high cure rate when managed appropriately. Advances in the understanding of PMBCL biological characteristics, coupled with improvements in diagnostic tools and therapeutic approaches, have significantly improved patient outcomes in recent years. In this article, we present a set of pragmatic guidelines developed by the Lymphoma Study Association (LYSA) for the management of PMBCL. These guidelines address key aspects of diagnosis, staging, response evaluation, and treatment, integrating the latest evidence from clinical trials, expert consensus, and real-world practice. The aim of the guidelines is to provide clinicians with a clear, practical framework to optimize care for patients with PMBCL, ensuring that the best available evidence is translated into clinical practice.

AB - Primary mediastinal B-cell lymphoma (PMBCL) is a distinct subtype of large B-cell lymphoma with unique clinical, histopathological, and molecular characteristics. Despite its aggressive nature, PMBCL has a high cure rate when managed appropriately. Advances in the understanding of PMBCL biological characteristics, coupled with improvements in diagnostic tools and therapeutic approaches, have significantly improved patient outcomes in recent years. In this article, we present a set of pragmatic guidelines developed by the Lymphoma Study Association (LYSA) for the management of PMBCL. These guidelines address key aspects of diagnosis, staging, response evaluation, and treatment, integrating the latest evidence from clinical trials, expert consensus, and real-world practice. The aim of the guidelines is to provide clinicians with a clear, practical framework to optimize care for patients with PMBCL, ensuring that the best available evidence is translated into clinical practice.

KW - Guidelines

KW - LYSA

KW - Primary mediastinal B-cell lymphoma

UR - http://www.scopus.com/inward/record.url?scp=105001338965&partnerID=8YFLogxK

U2 - 10.1016/j.ejca.2025.115369

DO - 10.1016/j.ejca.2025.115369

M3 - Review article

AN - SCOPUS:105001338965

SN - 0959-8049

VL - 220

JO - European Journal of Cancer

JF - European Journal of Cancer

M1 - 115369

ER -