Pro-ferroptotic fatty acid metabolism renders cancer cells immunogenic

Oliver Kepp; Guido Kroemer

doi:10.1016/j.trecan.2022.04.002

Pro-ferroptotic fatty acid metabolism renders cancer cells immunogenic

Oliver Kepp, Guido Kroemer

Résultats de recherche: Contribution à un journal › Brève enquête › Revue par des pairs

8 Citations (Scopus)

Résumé

Tumor cell-intrinsic metabolic features can affect the cancer-immunity dialogue. In a recent paper published in Cancer Cell, Liao et al. demonstrate that IFNγ produced by T cells, together with arachidonic acid, can induce acyl-CoA synthetase long-chain family member 4 (ACSL4)-mediated ferroptosis, correlating with increased immunosurveillance and response to checkpoint blockade.

langue originale	Anglais
Pages (de - à)	785-787
Nombre de pages	3
journal	Trends in Cancer
Volume	8
Numéro de publication	10
Les DOIs	https://doi.org/10.1016/j.trecan.2022.04.002
état	Publié - 1 oct. 2022

Accès au document

10.1016/j.trecan.2022.04.002

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Contient cette citation

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title = "Pro-ferroptotic fatty acid metabolism renders cancer cells immunogenic",

abstract = "Tumor cell-intrinsic metabolic features can affect the cancer-immunity dialogue. In a recent paper published in Cancer Cell, Liao et al. demonstrate that IFNγ produced by T cells, together with arachidonic acid, can induce acyl-CoA synthetase long-chain family member 4 (ACSL4)-mediated ferroptosis, correlating with increased immunosurveillance and response to checkpoint blockade.",

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