Prognostic factors in patients with soft palate squamous cell carcinoma

Antoine Schernberg; Charles Canova; Pierre Blanchard; Philippe Gorphe; Ingrid Breuskin; Haitham Mirghani; Antoine Moya-Plana; François Janot; Francois Bidault; Cyrus Chargari; Sara Bellefqih; Amandine Ruffier; Caroline Even; France Nguyen; Stéphane Temam; Yungan Tao

doi:10.1002/hed.25598

Prognostic factors in patients with soft palate squamous cell carcinoma

Antoine Schernberg, Charles Canova, Pierre Blanchard, Philippe Gorphe, Ingrid Breuskin, Haitham Mirghani, Antoine Moya-Plana, François Janot, Francois Bidault, Cyrus Chargari, Sara Bellefqih, Amandine Ruffier, Caroline Even, France Nguyen, Stéphane Temam, Yungan Tao

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

6 Citations (Scopus)

Résumé

Background: To define the prognostic factors associated with outcome in patients with soft palate squamous cell carcinoma (SCC). Methods: Previously untreated patients with soft palate and uvula SCC treated in our institution between 1997 and 2012 were collected. The prognostic value of clinical, hematological, and treatment characteristics was examined. Results: We identified 156 patients, median age 58 years, with 71% drinkers, 91% smokers; 19% had synchronous cancer. Front-line treatment was chemoradiotherapy in 58 (37%), radiotherapy alone in 60 (39%), surgery in 17 (11%), and induction chemotherapy in 21 patients (14%). The 5-year actuarial overall survival (OS) and progression-free survival (PFS) were 41% and 37%, respectively. In univariate analysis, T3-T4 vs T1-T2 stage, N2-N3 vs N0-N1 stage, and neutrophil count >7 g/L were associated with worse OS and PFS (P <.05). Conclusion: In patients with soft palate SCC, inflammation biomarkers were associated with OS.

langue originale	Anglais
Pages (de - à)	1441-1449
Nombre de pages	9
journal	Head and Neck
Volume	41
Numéro de publication	5
Les DOIs	https://doi.org/10.1002/hed.25598
état	Publié - 1 mai 2019

Accès au document

10.1002/hed.25598

Autres fichiers et liens

Lien vers la publication dans Scopus

Contient cette citation

@article{ae271e31d16b46cfb4ebe1f9e927394b,

title = "Prognostic factors in patients with soft palate squamous cell carcinoma",

abstract = "Background: To define the prognostic factors associated with outcome in patients with soft palate squamous cell carcinoma (SCC). Methods: Previously untreated patients with soft palate and uvula SCC treated in our institution between 1997 and 2012 were collected. The prognostic value of clinical, hematological, and treatment characteristics was examined. Results: We identified 156 patients, median age 58 years, with 71% drinkers, 91% smokers; 19% had synchronous cancer. Front-line treatment was chemoradiotherapy in 58 (37%), radiotherapy alone in 60 (39%), surgery in 17 (11%), and induction chemotherapy in 21 patients (14%). The 5-year actuarial overall survival (OS) and progression-free survival (PFS) were 41% and 37%, respectively. In univariate analysis, T3-T4 vs T1-T2 stage, N2-N3 vs N0-N1 stage, and neutrophil count >7 g/L were associated with worse OS and PFS (P <.05). Conclusion: In patients with soft palate SCC, inflammation biomarkers were associated with OS.",

keywords = "biomarkers, head and neck cancer, prognostic factor, squamous cell carcinoma",

author = "Antoine Schernberg and Charles Canova and Pierre Blanchard and Philippe Gorphe and Ingrid Breuskin and Haitham Mirghani and Antoine Moya-Plana and Fran{\c c}ois Janot and Francois Bidault and Cyrus Chargari and Sara Bellefqih and Amandine Ruffier and Caroline Even and France Nguyen and St{\'e}phane Temam and Yungan Tao",

note = "Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",

year = "2019",

month = may,

day = "1",

doi = "10.1002/hed.25598",

language = "English",

volume = "41",

pages = "1441--1449",

journal = "Head and Neck",

issn = "1043-3074",

number = "5",

}

TY - JOUR

T1 - Prognostic factors in patients with soft palate squamous cell carcinoma

AU - Schernberg, Antoine

AU - Canova, Charles

AU - Blanchard, Pierre

AU - Gorphe, Philippe

AU - Breuskin, Ingrid

AU - Mirghani, Haitham

AU - Moya-Plana, Antoine

AU - Janot, François

AU - Bidault, Francois

AU - Chargari, Cyrus

AU - Bellefqih, Sara

AU - Ruffier, Amandine

AU - Even, Caroline

AU - Nguyen, France

AU - Temam, Stéphane

AU - Tao, Yungan

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Background: To define the prognostic factors associated with outcome in patients with soft palate squamous cell carcinoma (SCC). Methods: Previously untreated patients with soft palate and uvula SCC treated in our institution between 1997 and 2012 were collected. The prognostic value of clinical, hematological, and treatment characteristics was examined. Results: We identified 156 patients, median age 58 years, with 71% drinkers, 91% smokers; 19% had synchronous cancer. Front-line treatment was chemoradiotherapy in 58 (37%), radiotherapy alone in 60 (39%), surgery in 17 (11%), and induction chemotherapy in 21 patients (14%). The 5-year actuarial overall survival (OS) and progression-free survival (PFS) were 41% and 37%, respectively. In univariate analysis, T3-T4 vs T1-T2 stage, N2-N3 vs N0-N1 stage, and neutrophil count >7 g/L were associated with worse OS and PFS (P <.05). Conclusion: In patients with soft palate SCC, inflammation biomarkers were associated with OS.

AB - Background: To define the prognostic factors associated with outcome in patients with soft palate squamous cell carcinoma (SCC). Methods: Previously untreated patients with soft palate and uvula SCC treated in our institution between 1997 and 2012 were collected. The prognostic value of clinical, hematological, and treatment characteristics was examined. Results: We identified 156 patients, median age 58 years, with 71% drinkers, 91% smokers; 19% had synchronous cancer. Front-line treatment was chemoradiotherapy in 58 (37%), radiotherapy alone in 60 (39%), surgery in 17 (11%), and induction chemotherapy in 21 patients (14%). The 5-year actuarial overall survival (OS) and progression-free survival (PFS) were 41% and 37%, respectively. In univariate analysis, T3-T4 vs T1-T2 stage, N2-N3 vs N0-N1 stage, and neutrophil count >7 g/L were associated with worse OS and PFS (P <.05). Conclusion: In patients with soft palate SCC, inflammation biomarkers were associated with OS.

KW - biomarkers

KW - head and neck cancer

KW - prognostic factor

KW - squamous cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=85059902321&partnerID=8YFLogxK

U2 - 10.1002/hed.25598

DO - 10.1002/hed.25598

M3 - Article

C2 - 30636178

AN - SCOPUS:85059902321

SN - 1043-3074

VL - 41

SP - 1441

EP - 1449

JO - Head and Neck

JF - Head and Neck

IS - 5

ER -