TY - JOUR
T1 - Prognostic Significance of the Microenvironment in Human Papillomavirus Oropharyngeal Carcinoma
T2 - A Systematic Review
AU - Baudouin, R.
AU - Hans, S.
AU - Lisan, Q.
AU - Morin, B.
AU - Adimi, Y.
AU - Martin, J.
AU - Lechien, J. R.
AU - Tartour, E.
AU - Badoual, C.
N1 - Publisher Copyright:
© 2023 The American Laryngological, Rhinological and Otological Society, Inc.
PY - 2024/4/1
Y1 - 2024/4/1
N2 - Objective: The immune microenvironment of HPV-associated (HPV+) oropharyngeal squamous cell carcinomas (OPSCCs) (HPV+OPSCCs) differs from that of HPV-independent oropharyngeal cancers (HPV-independent OPSCCs). The literature on the subject is very abundant, demanding an organized synthesis of this wealth of information to evaluate the hypothesis associating the favorable prognosis of HPV+OPSCC patients with a different immune microenvironment. A systematic review of the literature was conducted regarding the microenvironment of HPV+OPSCCs. Data Source: MEDLINE/PubMed, Embase, and Cochrane Library databases. Review Methods: A literature search was performed following PRISMA guidelines (Moher D. PLoS Med. 2009). The PEO (Population, Exposure, and Outcome) framework is detailed as follows: P: patients with oropharyngeal squamous cell carcinomas, E: human papillomavirus (HPV), and O: histological and immunological composition of the tumoral microenvironment (TME). No meta-analysis was performed. Results: From 1,202 studies that were screened, 58 studies were included (n = 6,474 patients; n = 3,581 (55%) HPV+OPSCCs and n = 2,861(45%) HPV-independent OPSCCs). The presence of tumor-infiltrating lymphocytes (TIL), CD3+ in 1,733 patients, CD4+ in 520 patients, and CD8+ (cytotoxic T lymphocytes (CTL)) in 3,104 patients, and high levels of PD-L1 expression in 1,222 patients is strongly correlated with an improved clinical outcome in HPV+OPSCCs. Conclusion: This systematic review provides the most comprehensive information on the immune microenvironment of HPV+OPSCCs to date. Tumor-infiltrating lymphocytes and PD-L1 expression are associated with a favorable prognosis. B, CD8+ and resident memory cells densities are higher in HPV+OPSCCs. The importance of myeloid lineages is still a matter of debate and research. Level of Evidence: NA Laryngoscope, 134:1507–1516, 2024.
AB - Objective: The immune microenvironment of HPV-associated (HPV+) oropharyngeal squamous cell carcinomas (OPSCCs) (HPV+OPSCCs) differs from that of HPV-independent oropharyngeal cancers (HPV-independent OPSCCs). The literature on the subject is very abundant, demanding an organized synthesis of this wealth of information to evaluate the hypothesis associating the favorable prognosis of HPV+OPSCC patients with a different immune microenvironment. A systematic review of the literature was conducted regarding the microenvironment of HPV+OPSCCs. Data Source: MEDLINE/PubMed, Embase, and Cochrane Library databases. Review Methods: A literature search was performed following PRISMA guidelines (Moher D. PLoS Med. 2009). The PEO (Population, Exposure, and Outcome) framework is detailed as follows: P: patients with oropharyngeal squamous cell carcinomas, E: human papillomavirus (HPV), and O: histological and immunological composition of the tumoral microenvironment (TME). No meta-analysis was performed. Results: From 1,202 studies that were screened, 58 studies were included (n = 6,474 patients; n = 3,581 (55%) HPV+OPSCCs and n = 2,861(45%) HPV-independent OPSCCs). The presence of tumor-infiltrating lymphocytes (TIL), CD3+ in 1,733 patients, CD4+ in 520 patients, and CD8+ (cytotoxic T lymphocytes (CTL)) in 3,104 patients, and high levels of PD-L1 expression in 1,222 patients is strongly correlated with an improved clinical outcome in HPV+OPSCCs. Conclusion: This systematic review provides the most comprehensive information on the immune microenvironment of HPV+OPSCCs to date. Tumor-infiltrating lymphocytes and PD-L1 expression are associated with a favorable prognosis. B, CD8+ and resident memory cells densities are higher in HPV+OPSCCs. The importance of myeloid lineages is still a matter of debate and research. Level of Evidence: NA Laryngoscope, 134:1507–1516, 2024.
KW - HPV
KW - immunology
KW - oropharyngeal tumor
KW - squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85168878021&partnerID=8YFLogxK
U2 - 10.1002/lary.31010
DO - 10.1002/lary.31010
M3 - Review article
C2 - 37642393
AN - SCOPUS:85168878021
SN - 0023-852X
VL - 134
SP - 1507
EP - 1516
JO - Laryngoscope
JF - Laryngoscope
IS - 4
ER -