Prophylactic nodal radiotherapy in prostate cancer

R. Bourdais; S. Achkar; L. Chauffert-Yvart; D. Pasquier; P. Sargos; P. Blanchard; I. Latorzeff

doi:10.1016/j.canrad.2019.07.149

Prophylactic nodal radiotherapy in prostate cancer

Titre traduit de la contribution: Irradiation ganglionnaire prophylactique des cancers de prostate

R. Bourdais, S. Achkar, L. Chauffert-Yvart, D. Pasquier, P. Sargos, P. Blanchard, I. Latorzeff

Résultats de recherche: Contribution à un journal › Brève enquête › Revue par des pairs

Résumé

The risk of lymph node invasion, in case of prostate cancer, increases with the clinical stage of the disease, the Gleason score of prostate biopsies and the value of PSA at diagnosis. Historically, beyond 15% risk of lymph node involvement, irradiation of the pelvic areas was performed with prostate radiotherapy (RT) to take into account the risk of occult lymph node metastasis in patients at risk, but the benefit of this therapeutic approach remains to be demonstrated. The data from surgical lymph node dissection seem to question the risk levels, the escalation of the dose on the prostate increases the survival without relapse, the contribution of image-guided radiotherapy, (IGRT) and modulation of intensity (IMRT), decreases the toxicity of pelvic RT. This article reviews the principles of prophylactic ganglion irradiation for prostate cancer and discusses its relevance, current uncertainties, and prospective trials.

Titre traduit de la contribution	Irradiation ganglionnaire prophylactique des cancers de prostate
langue originale	Anglais
Pages (de - à)	688-695
Nombre de pages	8
journal	Cancer/Radiotherapie
Volume	23
Numéro de publication	6-7
Les DOIs	https://doi.org/10.1016/j.canrad.2019.07.149
état	Publié - 1 oct. 2019

Accès au document

10.1016/j.canrad.2019.07.149

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title = "Prophylactic nodal radiotherapy in prostate cancer",

abstract = "The risk of lymph node invasion, in case of prostate cancer, increases with the clinical stage of the disease, the Gleason score of prostate biopsies and the value of PSA at diagnosis. Historically, beyond 15% risk of lymph node involvement, irradiation of the pelvic areas was performed with prostate radiotherapy (RT) to take into account the risk of occult lymph node metastasis in patients at risk, but the benefit of this therapeutic approach remains to be demonstrated. The data from surgical lymph node dissection seem to question the risk levels, the escalation of the dose on the prostate increases the survival without relapse, the contribution of image-guided radiotherapy, (IGRT) and modulation of intensity (IMRT), decreases the toxicity of pelvic RT. This article reviews the principles of prophylactic ganglion irradiation for prostate cancer and discusses its relevance, current uncertainties, and prospective trials.",

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AU - Bourdais, R.

AU - Achkar, S.

AU - Chauffert-Yvart, L.

AU - Pasquier, D.

AU - Sargos, P.

AU - Blanchard, P.

AU - Latorzeff, I.

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AB - The risk of lymph node invasion, in case of prostate cancer, increases with the clinical stage of the disease, the Gleason score of prostate biopsies and the value of PSA at diagnosis. Historically, beyond 15% risk of lymph node involvement, irradiation of the pelvic areas was performed with prostate radiotherapy (RT) to take into account the risk of occult lymph node metastasis in patients at risk, but the benefit of this therapeutic approach remains to be demonstrated. The data from surgical lymph node dissection seem to question the risk levels, the escalation of the dose on the prostate increases the survival without relapse, the contribution of image-guided radiotherapy, (IGRT) and modulation of intensity (IMRT), decreases the toxicity of pelvic RT. This article reviews the principles of prophylactic ganglion irradiation for prostate cancer and discusses its relevance, current uncertainties, and prospective trials.

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KW - Prostate cancer

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