Propriétés et rôles biologiques des protéines TET au cours du développement et de l'hématopoïèse

Emna Mahfoudhi; Lise Secardin; Laurianne Scourzic; Olivier Bernard; William Vainchenker; Isabelle Plo

doi:10.1051/medsci/20153103012

Propriétés et rôles biologiques des protéines TET au cours du développement et de l'hématopoïèse

Emna Mahfoudhi, Lise Secardin, Laurianne Scourzic, Olivier Bernard, William Vainchenker, Isabelle Plo

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

5 Citations (Scopus)

Résumé

DNA methylation is associated with a large number of biological processes and mainly concerns the cytosine methylation at position 5 (5-mC). An active demethylation mechanism was highlighted in 2009 following the discovery that TET proteins were enzymes implicated in the hydroxylation of 5-mC to 5-hydroxymethylcytosine. Simultaneously, other studies showed frequent acquired TET2 mutations in hematological malignancies and have depicted their role in their pathogenesis. An entire field of research has developed rapidly showing that these proteins are involved in many biological processes.

Titre traduit de la contribution	Properties and biological roles of TET proteins during embryogenesis and in hematopoiesis
langue originale	Français
Pages (de - à)	268-274
Nombre de pages	7
journal	Medecine/Sciences
Volume	31
Numéro de publication	3
Les DOIs	https://doi.org/10.1051/medsci/20153103012
état	Publié - 1 mars 2015

Accès au document

10.1051/medsci/20153103012

Autres fichiers et liens

Lien vers la publication dans Scopus

Contient cette citation

@article{dd7c8350a1d147219328934773df9aba,

title = "Propri{\'e}t{\'e}s et r{\^o}les biologiques des prot{\'e}ines TET au cours du d{\'e}veloppement et de l'h{\'e}matopo{\"i}{\`e}se",

abstract = "DNA methylation is associated with a large number of biological processes and mainly concerns the cytosine methylation at position 5 (5-mC). An active demethylation mechanism was highlighted in 2009 following the discovery that TET proteins were enzymes implicated in the hydroxylation of 5-mC to 5-hydroxymethylcytosine. Simultaneously, other studies showed frequent acquired TET2 mutations in hematological malignancies and have depicted their role in their pathogenesis. An entire field of research has developed rapidly showing that these proteins are involved in many biological processes.",

author = "Emna Mahfoudhi and Lise Secardin and Laurianne Scourzic and Olivier Bernard and William Vainchenker and Isabelle Plo",

note = "Publisher Copyright: {\textcopyright} 2015 m{\'e}decine/sciences - Inserm.",

year = "2015",

month = mar,

day = "1",

doi = "10.1051/medsci/20153103012",

language = "Fran{\c c}ais",

volume = "31",

pages = "268--274",

journal = "Medecine/Sciences",

issn = "0767-0974",

number = "3",

}

TY - JOUR

T1 - Propriétés et rôles biologiques des protéines TET au cours du développement et de l'hématopoïèse

AU - Mahfoudhi, Emna

AU - Secardin, Lise

AU - Scourzic, Laurianne

AU - Bernard, Olivier

AU - Vainchenker, William

AU - Plo, Isabelle

PY - 2015/3/1

Y1 - 2015/3/1

N2 - DNA methylation is associated with a large number of biological processes and mainly concerns the cytosine methylation at position 5 (5-mC). An active demethylation mechanism was highlighted in 2009 following the discovery that TET proteins were enzymes implicated in the hydroxylation of 5-mC to 5-hydroxymethylcytosine. Simultaneously, other studies showed frequent acquired TET2 mutations in hematological malignancies and have depicted their role in their pathogenesis. An entire field of research has developed rapidly showing that these proteins are involved in many biological processes.

AB - DNA methylation is associated with a large number of biological processes and mainly concerns the cytosine methylation at position 5 (5-mC). An active demethylation mechanism was highlighted in 2009 following the discovery that TET proteins were enzymes implicated in the hydroxylation of 5-mC to 5-hydroxymethylcytosine. Simultaneously, other studies showed frequent acquired TET2 mutations in hematological malignancies and have depicted their role in their pathogenesis. An entire field of research has developed rapidly showing that these proteins are involved in many biological processes.

UR - http://www.scopus.com/inward/record.url?scp=84927731771&partnerID=8YFLogxK

U2 - 10.1051/medsci/20153103012

DO - 10.1051/medsci/20153103012

M3 - Article

C2 - 25855280

AN - SCOPUS:84927731771

SN - 0767-0974

VL - 31

SP - 268

EP - 274

JO - Medecine/Sciences

JF - Medecine/Sciences

IS - 3

ER -