TY - JOUR
T1 - Pure red cell aplasia with thymoma
AU - Alexandrova, K.
AU - Hadjiev, E.
AU - Popova, D.
AU - Petrov, D.
AU - Apostolov, P.
PY - 2003/12/1
Y1 - 2003/12/1
N2 - Pure red cell aplasia is a rare hematological disorder, frequently associated with viral infection, chronic inflammation, lymphoproliferative and myeloproliferative disorders, tumors. We present a case of a 55-year-old female who has been treated for myasthenia gravis for 2 years. In October 2002, the patient was presented with symptoms of anemia. The laboratory study revealed hemoglobin 50 g/l, reticulocytes 0%, leucocytes 6.5 G/I and platelets 179 G/I. The bone marrow aspiration showed severe erythroid hypoplasia (<5%) with normal granulocytopoiesis and normal megakaryocyte density. The computed tomography (CT) scan of the thorax revealed a retrosternal mass in the anterior mediastinum, surgically resected. The histological examination showed a thymoma. Serology for EBV, CMV, HBC, HbsAg was negative. Three months after the thymectomy, the patient showed no manifestations of myasthenia gravis, but was with persisting of the severe anemia which required hemotransfusions. Treatment with prednisolone 1 mg/kg BW was started, without success. This made necessary the inclusion of immunosuppressive therapy with cyclophosphamid. The observation of this patient is being followed.
AB - Pure red cell aplasia is a rare hematological disorder, frequently associated with viral infection, chronic inflammation, lymphoproliferative and myeloproliferative disorders, tumors. We present a case of a 55-year-old female who has been treated for myasthenia gravis for 2 years. In October 2002, the patient was presented with symptoms of anemia. The laboratory study revealed hemoglobin 50 g/l, reticulocytes 0%, leucocytes 6.5 G/I and platelets 179 G/I. The bone marrow aspiration showed severe erythroid hypoplasia (<5%) with normal granulocytopoiesis and normal megakaryocyte density. The computed tomography (CT) scan of the thorax revealed a retrosternal mass in the anterior mediastinum, surgically resected. The histological examination showed a thymoma. Serology for EBV, CMV, HBC, HbsAg was negative. Three months after the thymectomy, the patient showed no manifestations of myasthenia gravis, but was with persisting of the severe anemia which required hemotransfusions. Treatment with prednisolone 1 mg/kg BW was started, without success. This made necessary the inclusion of immunosuppressive therapy with cyclophosphamid. The observation of this patient is being followed.
KW - Anemia
KW - Thymoma
UR - http://www.scopus.com/inward/record.url?scp=4444346911&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:4444346911
SN - 0861-7880
VL - 39
SP - 55
EP - 59
JO - Clinical and Transfusion Haematology
JF - Clinical and Transfusion Haematology
IS - 3-4
ER -