Rôle des cellules dendritiques dans la modulation des effecteurs de l'immunité innée

M. Terme; C. Masurier; N. Fernandez; M. N. Lacassagne; J. P. Marolleau; L. Zitvogel

doi:10.1016/S0369-8114(01)00170-5

Rôle des cellules dendritiques dans la modulation des effecteurs de l'immunité innée

M. Terme, C. Masurier, N. Fernandez, M. N. Lacassagne, J. P. Marolleau, L. Zitvogel

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

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Résumé

CD8+ cytotoxic T lymphocytes (CTL), specifically directed against tumor-associated antigens, can be used in immunotherapy as effector cells in order to induce antitumor immune response. However, natural killer (NK) cells, that belong to the innate immune system, might also play a role on the anti-tumoral immune response. Our data show that quiescent NK cells can be activated by direct cell contact with dendritic cells (CD). Such a NK cells activating ability places DC at the frontier between innate and cognate immunity and then may encourage their use in clinical trials designed to elicit both CTL and NK responses.

Titre traduit de la contribution	Role of dendritic cells in the modulation of innate immunity effectors
langue originale	Français
Pages (de - à)	475-477
Nombre de pages	3
journal	Pathologie Biologie
Volume	49
Numéro de publication	6
Les DOIs	https://doi.org/10.1016/S0369-8114(01)00170-5
état	Publié - 1 janv. 2001

mots-clés

Antitumor response
Dendritic cells
Innate immunity
NK cells

Accès au document

10.1016/S0369-8114(01)00170-5

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Contient cette citation

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title = "R{\^o}le des cellules dendritiques dans la modulation des effecteurs de l'immunit{\'e} inn{\'e}e",

abstract = "CD8+ cytotoxic T lymphocytes (CTL), specifically directed against tumor-associated antigens, can be used in immunotherapy as effector cells in order to induce antitumor immune response. However, natural killer (NK) cells, that belong to the innate immune system, might also play a role on the anti-tumoral immune response. Our data show that quiescent NK cells can be activated by direct cell contact with dendritic cells (CD). Such a NK cells activating ability places DC at the frontier between innate and cognate immunity and then may encourage their use in clinical trials designed to elicit both CTL and NK responses.",

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AU - Terme, M.

AU - Masurier, C.

AU - Fernandez, N.

AU - Lacassagne, M. N.

AU - Marolleau, J. P.

AU - Zitvogel, L.

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AB - CD8+ cytotoxic T lymphocytes (CTL), specifically directed against tumor-associated antigens, can be used in immunotherapy as effector cells in order to induce antitumor immune response. However, natural killer (NK) cells, that belong to the innate immune system, might also play a role on the anti-tumoral immune response. Our data show that quiescent NK cells can be activated by direct cell contact with dendritic cells (CD). Such a NK cells activating ability places DC at the frontier between innate and cognate immunity and then may encourage their use in clinical trials designed to elicit both CTL and NK responses.

KW - Antitumor response

KW - Dendritic cells

KW - Innate immunity

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