Rôle du microbiote intestinal dans la réponse aux thérapies anti-tumorales

Marie Vétizou, Romain Daillère, Laurence Zitvogel

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    6 Citations (Scopus)

    Résumé

    The gut microbiota is known to affect digestion, protection against pathogens infection, immune system maturation and enteric nervous system development, but others links have also been established with diabetes, obesity, autism and cancer. Lately, bacterial species from the gut have been involved in tumor immunosurveillance. Natural or mediated by treatment such as chemotherapy or immunotherapy, anti-tumoral immune responses seem to rely on gut microbiota. The bacteria involved and their mechanisms of action are different according to the treatment of interest. Nevertheless, modulation of gut microbiota represents a great potential with the development of onco-micro-biotics to optimize the response to cancer therapies.

    Titre traduit de la contributionGut microbiota and efficacy of cancer therapies
    langue originaleFrançais
    Pages (de - à)51-67
    Nombre de pages17
    journalBiologie Aujourd'hui
    Volume211
    Numéro de publication1
    Les DOIs
    étatPublié - 1 janv. 2017

    mots-clés

    • Anti-CTLA-4 antibody
    • Cancer
    • Cyclophosphamide
    • Gut microbiota
    • Immunotherapy

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