Rabbit VX2 Liver Tumor Model: A Review of Clinical, Biology, Histology, and Tumor Microenvironment Characteristics

Florentina Pascale, Jean Pierre Pelage, Michel Wassef, Saïda H. Ghegediban, Jean Pierre Saint-Maurice, Thierry De Baere, Alban Denys, Rafael Duran, Frédéric Deschamps, Olivier Pellerin, Noboru Maeda, Alexandre Laurent, Julien Namur

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    6 Citations (Scopus)

    Résumé

    The rabbit VX2 is a large animal model of cancer used for decades by interventional radiologists to demonstrate the efficacy of various locoregional treatments against liver tumors. What do we know about this tumor in the new era of targeted therapy and immune-oncology? The present paper describes the current knowledge on the clinics, biology, histopathology, and tumor microenvironment of VX2 based on a literature review of 741 publications in the liver and in other organs. It reveals the resemblance with human cancer (anatomy, vascularity, angiogenic profile, drug sensitivity, immune microenvironment), the differences (etiology, growth rate, histology), and the questions still poorly explored (serum and tissue biomarkers, genomic alterations, immune checkpoint inhibitors efficacy).

    langue originaleAnglais
    Numéro d'article871829
    journalFrontiers in Oncology
    Volume12
    Les DOIs
    étatPublié - 10 mai 2022

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