Radiation-Induced Hypothyroidism After Radical Intensity Modulated Radiation Therapy for Oropharyngeal Carcinoma

Mona Kamal, Christopher Ryan Peeler, Pablo Yepes, Abdallah S.R. Mohamed, Pierre Blanchard, Steven Frank, Lei Chen, Amit Jethanandani, Rohit Kuruvilla, Benjamin Greiner, Jared Harp, Robin Granberry, Vivek Mehta, Crosby Rock, Katherine Hutcheson, Carlos Cardenas, G. Brandon Gunn, Clifton Fuller, Dragan Mirkovic

Résultats de recherche: Contribution à un journalArticleRevue par des pairs

17 Citations (Scopus)

Résumé

Purpose: To evaluate 2 published normal tissue complication probability models for radiation-induced hypothyroidism (RHT) on a large cohort of oropharyngeal carcinoma (OPC) patients who were treated with intensity-modulated radiation therapy (IMRT). Methods and Materials: OPC patients treated with retrievable IMRT Digital Imaging and Communications in Medicine (DICOMs) data and available baseline and follow-up thyroid function tests were included. Mean dose (Dmean) to the thyroid gland (TG) and its volume were calculated. The study outcome was clinical HT at least 6 months after radiation therapy, which was defined as grade ≥2 HT per Common Terminology Criteria for Adverse Events grading system (symptomatic hypothyroidism that required thyroid replacement therapy). Regression analyses and Wilcoxon rank-sum test were used. Receiver operating characteristic curves and area under the curve for the fitted model were calculated. Results: In the study, 360 OPC patients were included. The median age was 58 years. Most tumors (51%) originated from the base of tongue. IMRT-split field was used in 95%, and median radiation therapy dose was 69.96 Gy. In the study, 233 patients (65%) developed clinical RHT that required thyroid replacement therapy. On multivariate analysis higher Dmean and smaller TG volume maintained the statistically significant association with the risk of clinical RHT (P < .0001). Dmean was significantly higher in patients with clinical RHT versus those without (50 vs 42 Gy, P < .0001). Patients with RHT had smaller TG volume compared with those without (11.8 compared with 12.8 mL, P < .0001). AUC of 0.72 and 0.66 were identified for fitted model versus for the applied Boomsma et al and Cella et al models, respectively. Conclusions: Volume and Dmean of the TG are important predictors of clinical RHT and shall be integrated into normal tissue complication probability models for RHT. Dmean and thyroid volume should be considered during the IMRT plan optimization in OPC patients.

langue originaleAnglais
Pages (de - à)111-119
Nombre de pages9
journalAdvances in Radiation Oncology
Volume5
Numéro de publication1
Les DOIs
étatPublié - 1 janv. 2020
Modification externeOui

Contient cette citation