Radio-induced lymphopenia in the era of anti-cancer immunotherapy

François de Kermenguy; Lydia Meziani; Michele Mondini; Céline Clémenson; Daphné Morel; Eric Deutsch; Charlotte Robert

doi:10.1016/bs.ircmb.2023.03.002

Radio-induced lymphopenia in the era of anti-cancer immunotherapy

François de Kermenguy, Lydia Meziani, Michele Mondini, Céline Clémenson, Daphné Morel, Eric Deutsch, Charlotte Robert

Résultats de recherche: Le chapitre dans un livre, un rapport, une anthologie ou une collection › !!Chapter › Revue par des pairs

12 Citations (Scopus)

Résumé

Radiation-induced lymphopenia (RIL) is characterized by a significant decrease in the absolute number of lymphocytes circulating in the blood after radiotherapy. With the major shift in cancer management initiated by cancer immunotherapy (IT), the reduction of incidence of RIL appears today as an extremely promising way of potentiating the synergy between radiotherapy and immunotherapy. However, the causes of RIL and mechanisms involved are still poorly understood. Improving our knowledge on RIL is therefore essential to limit it and thus improve the quality of care delivered to patients. The objective of this review is to provide a global view of RIL from a clinical point of view, with particular emphasis on recent knowledge and avenues explored to explain RIL and especially its depletion and remission kinetics. An opening on treatment concepts to be rethought is conducted in the context of combined RT/IT treatments.

langue originale	Anglais
titre	Ionizing Radiation and the Immune Response - Part B
rédacteurs en chef	Céline Mirjolet, Lorenzo Galluzzi
Editeur	Elsevier Inc.
Pages	1-30
Nombre de pages	30
ISBN (imprimé)	9780443184321
Les DOIs	https://doi.org/10.1016/bs.ircmb.2023.03.002
état	Publié - 1 janv. 2023

Série de publications

Nom	International Review of Cell and Molecular Biology
Volume	378
ISSN (imprimé)	1937-6448

Accès au document

10.1016/bs.ircmb.2023.03.002

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Contient cette citation

de Kermenguy, F., Meziani, L., Mondini, M., Clémenson, C., Morel, D., Deutsch, E., & Robert, C. (2023). Radio-induced lymphopenia in the era of anti-cancer immunotherapy. Dans C. Mirjolet, & L. Galluzzi (eds.), Ionizing Radiation and the Immune Response - Part B (p. 1-30). (International Review of Cell and Molecular Biology; Vol 378). Elsevier Inc.. https://doi.org/10.1016/bs.ircmb.2023.03.002

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abstract = "Radiation-induced lymphopenia (RIL) is characterized by a significant decrease in the absolute number of lymphocytes circulating in the blood after radiotherapy. With the major shift in cancer management initiated by cancer immunotherapy (IT), the reduction of incidence of RIL appears today as an extremely promising way of potentiating the synergy between radiotherapy and immunotherapy. However, the causes of RIL and mechanisms involved are still poorly understood. Improving our knowledge on RIL is therefore essential to limit it and thus improve the quality of care delivered to patients. The objective of this review is to provide a global view of RIL from a clinical point of view, with particular emphasis on recent knowledge and avenues explored to explain RIL and especially its depletion and remission kinetics. An opening on treatment concepts to be rethought is conducted in the context of combined RT/IT treatments.",

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de Kermenguy, F, Meziani, L, Mondini, M, Clémenson, C, Morel, D, Deutsch, E & Robert, C 2023, Radio-induced lymphopenia in the era of anti-cancer immunotherapy. Dans C Mirjolet & L Galluzzi (eds), Ionizing Radiation and the Immune Response - Part B. International Review of Cell and Molecular Biology, VOL. 378, Elsevier Inc., p. 1-30. https://doi.org/10.1016/bs.ircmb.2023.03.002

Radio-induced lymphopenia in the era of anti-cancer immunotherapy. / de Kermenguy, François; Meziani, Lydia; Mondini, Michele et al.
Ionizing Radiation and the Immune Response - Part B. Ed. / Céline Mirjolet; Lorenzo Galluzzi. Elsevier Inc., 2023. p. 1-30 (International Review of Cell and Molecular Biology; Vol 378).

Résultats de recherche: Le chapitre dans un livre, un rapport, une anthologie ou une collection › !!Chapter › Revue par des pairs

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AU - Deutsch, Eric

AU - Robert, Charlotte

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