Rationale for the use of upfront whole brain irradiation in patients with brain metastases from breast cancer

Agnes V. Tallet; David Azria; Emilie Le Rhun; Fabrice Barlesi; Antoine F. Carpentier; Antony Gonçalves; Sophie Taillibert; Frédéric Dhermain; Jean Philippe Spano; Philippe Metellus

doi:10.3390/ijms15058138

Rationale for the use of upfront whole brain irradiation in patients with brain metastases from breast cancer

Agnes V. Tallet, David Azria, Emilie Le Rhun, Fabrice Barlesi, Antoine F. Carpentier, Antony Gonçalves, Sophie Taillibert, Frédéric Dhermain, Jean Philippe Spano, Philippe Metellus

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5 Citations (Scopus)

Résumé

Breast cancer is the second most common cause of brain metastases and deserves particular attention in relation to current prolonged survival of patients with metastatic disease. Advances in both systemic therapies and brain local treatments (surgery and stereotactic radiosurgery) have led to a reappraisal of brain metastases management. With respect to this, the literature review presented here was conducted in an attempt to collect medical evidence-based data on the use of whole-brain radiotherapy for the treatment of brain metastases from breast cancer. In addition, this study discusses here the potential differences in outcomes between patients with brain metastases from breast cancer and those with brain metastases from other primary malignancies and the potential implications within a treatment strategy.

langue originale	Anglais
Pages (de - à)	8138-8152
Nombre de pages	15
journal	International Journal of Molecular Sciences
Volume	15
Numéro de publication	5
Les DOIs	https://doi.org/10.3390/ijms15058138
état	Publié - 8 mai 2014

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10.3390/ijms15058138

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title = "Rationale for the use of upfront whole brain irradiation in patients with brain metastases from breast cancer",

abstract = "Breast cancer is the second most common cause of brain metastases and deserves particular attention in relation to current prolonged survival of patients with metastatic disease. Advances in both systemic therapies and brain local treatments (surgery and stereotactic radiosurgery) have led to a reappraisal of brain metastases management. With respect to this, the literature review presented here was conducted in an attempt to collect medical evidence-based data on the use of whole-brain radiotherapy for the treatment of brain metastases from breast cancer. In addition, this study discusses here the potential differences in outcomes between patients with brain metastases from breast cancer and those with brain metastases from other primary malignancies and the potential implications within a treatment strategy.",

keywords = "Brain metastases, Breast cancer, Controlled extra-cranial disease, Overall survival, Whole brain radiation therapy",

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T1 - Rationale for the use of upfront whole brain irradiation in patients with brain metastases from breast cancer

AU - Tallet, Agnes V.

AU - Azria, David

AU - Le Rhun, Emilie

AU - Barlesi, Fabrice

AU - Carpentier, Antoine F.

AU - Gonçalves, Antony

AU - Taillibert, Sophie

AU - Dhermain, Frédéric

AU - Spano, Jean Philippe

AU - Metellus, Philippe

PY - 2014/5/8

Y1 - 2014/5/8

N2 - Breast cancer is the second most common cause of brain metastases and deserves particular attention in relation to current prolonged survival of patients with metastatic disease. Advances in both systemic therapies and brain local treatments (surgery and stereotactic radiosurgery) have led to a reappraisal of brain metastases management. With respect to this, the literature review presented here was conducted in an attempt to collect medical evidence-based data on the use of whole-brain radiotherapy for the treatment of brain metastases from breast cancer. In addition, this study discusses here the potential differences in outcomes between patients with brain metastases from breast cancer and those with brain metastases from other primary malignancies and the potential implications within a treatment strategy.

AB - Breast cancer is the second most common cause of brain metastases and deserves particular attention in relation to current prolonged survival of patients with metastatic disease. Advances in both systemic therapies and brain local treatments (surgery and stereotactic radiosurgery) have led to a reappraisal of brain metastases management. With respect to this, the literature review presented here was conducted in an attempt to collect medical evidence-based data on the use of whole-brain radiotherapy for the treatment of brain metastases from breast cancer. In addition, this study discusses here the potential differences in outcomes between patients with brain metastases from breast cancer and those with brain metastases from other primary malignancies and the potential implications within a treatment strategy.

KW - Brain metastases

KW - Breast cancer

KW - Controlled extra-cranial disease

KW - Overall survival

KW - Whole brain radiation therapy

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