Real-world safety and effectiveness of regorafenib in metastatic colorectal cancer: The French CORRELATE cohort

Jean Philippe Metges, Dominique Genet, David Tougeron, Catherine Ligeza, Michel Ducreux, Christophe Borg, Rosine Guimbaud, Jean Marc Phelip, Louis Marie Dourthe, Stefano Kim

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    4 Citations (Scopus)

    Résumé

    Aim: We report real-world evidence with regorafenib in previously treated metastatic colorectal cancer from the French cohort of the international, prospective, observational CORRELATE study. Patients & methods: Patients receiving regorafenib according to French health authority approval were included. The primary end point was treatment-emergent adverse events. Overall survival and progression-free survival were secondary end points. Results: Two hundred and forty-two patients (61% male, median age: 66 years) were enrolled. The most common grade ≥3 drug-related treatment-emergent adverse events were hand-foot skin reaction (10.3%), asthenia/fatigue (9.9/1.2%) and hypertension (6.2%). Median overall survival and progression-free survival were 6.8 (95% CI: 6.3-7.6) and 2.8 months (95% CI: 2.6-3.0), respectively. Conclusion: The real-world safety and effectiveness data of regorafenib in metastatic colorectal cancer in France align with findings from Phase III clinical trials and the global CORRELATE population.

    langue originaleAnglais
    Pages (de - à)3343-3353
    Nombre de pages11
    journalFuture Oncology
    Volume17
    Numéro de publication25
    Les DOIs
    étatPublié - 1 sept. 2021

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