Recent advances in managing gastrointestinal stromal tumor

Florence Duffaud, Axel Le Cesne

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    9 Citations (Scopus)

    Résumé

    Constitutive activating mutations in KIT and platelet-derived growth factor receptor α (PDGFRα) are heavily involved in the pathobiology of gastrointestinal stromal tumors (GISTs). This disease has served as an effective "proof-of-concept" model for targeting gain-of-function kinase mutations in cancer. This review discusses the current standard of care in terms of pharmacotherapy in the management of localized and metastatic GISTs.

    langue originaleAnglais
    Numéro d'article1689
    journalF1000Research
    Volume6
    Les DOIs
    étatPublié - 1 janv. 2017

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