TY - JOUR
T1 - Recommandations pour la prise en charge de l'insulinome malin
AU - Baudin, Éric
AU - Caron, Philippe
AU - Lombard-Bohas, Catherine
AU - Tabarin, Antoine
AU - Mitry, Emmanuel
AU - Reznick, Yves
AU - Taieb, David
AU - Pattou, François
AU - Goudet, Pierre
AU - Vezzosi, Delphine
AU - Scoazec, Jean Yves
AU - Cadiot, Guillaume
AU - Borson-Chazot, Françoise
AU - Do Cao, Christine
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Insulinoma are malignant in 4to 14% of cases. Their rarity and the sparse data available in the literature have limited publication of specific guidelines for their management. The following review aim to provide up-to-date recommendations on initial evaluation including pathologic grading, measures to control hypoglycemia, antitumor strategies and long term follow-up. Will be discussed in detail respective indications of surgery, diazoxide, somatostatin analogs, everolimus, sunitinib, liver directed treatments including arterial embolization, chemotherapy and radiometabolic therapy. A Medline search using terms"insulinoma", "neuroendocrine pancreatic tumors", "islet cell carcinoma", "malignant insulinoma" was performed limiting the selection to English language articles and adult age cases, along with cross referencing.
AB - Insulinoma are malignant in 4to 14% of cases. Their rarity and the sparse data available in the literature have limited publication of specific guidelines for their management. The following review aim to provide up-to-date recommendations on initial evaluation including pathologic grading, measures to control hypoglycemia, antitumor strategies and long term follow-up. Will be discussed in detail respective indications of surgery, diazoxide, somatostatin analogs, everolimus, sunitinib, liver directed treatments including arterial embolization, chemotherapy and radiometabolic therapy. A Medline search using terms"insulinoma", "neuroendocrine pancreatic tumors", "islet cell carcinoma", "malignant insulinoma" was performed limiting the selection to English language articles and adult age cases, along with cross referencing.
UR - http://www.scopus.com/inward/record.url?scp=84902523669&partnerID=8YFLogxK
U2 - 10.1016/j.lpm.2013.08.007
DO - 10.1016/j.lpm.2013.08.007
M3 - Article
C2 - 24857257
AN - SCOPUS:84902523669
SN - 0755-4982
VL - 43
SP - 645
EP - 659
JO - Presse Medicale
JF - Presse Medicale
IS - 6P1
ER -