Résumé
Loss of heterozygosity or HLA loss is a genomic-type escape mechanism highlighted in certain types of relapses after allogeneic hematopoietic stem cell transplantation with a non-HLA identical donor, and especially after haplo-identical transplantation. The diagnosis must be made with certainty because the result conditions the therapy. In this article, the different mechanisms and techniques that can be used for the diagnosis of loss of heterozygosity, as well as the therapeutic options are reviewed, making it possible to establish clinico-biological recommendations for the diagnosis confirmation and management of the patients in relapse.
Titre traduit de la contribution | Perte d'hétérozygotie HLA dans les rechutes après greffes de cellules souches hématopoïétiques avec donneur non HLA identique: recommandations de la Société francophone de greffe de moelle et de thérapie cellulaire (SFGM-TC) |
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langue originale | Anglais |
Pages (de - à) | S14-S21 |
journal | Bulletin du Cancer |
Volume | 111 |
Numéro de publication | 2 |
Les DOIs | |
état | Publié - 1 févr. 2024 |