TY - JOUR
T1 - Relationships between regional radiation doses and cognitive decline in children treated with cranio-spinal irradiation for posterior fossa tumors
AU - de Speville, Elodie Doger
AU - Robert, Charlotte
AU - Perez-Guevara, Martin
AU - Grigis, Antoine
AU - Bolle, Stephanie
AU - Pinaud, Clemence
AU - Dufour, Christelle
AU - Beaudré, Anne
AU - Kieffer, Virginie
AU - Longaud, Audrey
AU - Grill, Jacques
AU - Valteau-Couanet, Dominique
AU - Deutsch, Eric
AU - Lefkopoulos, Dimitri
AU - Chiron, Catherine
AU - Hertz-Pannier, Lucie
AU - Noulhiane, Marion
N1 - Publisher Copyright:
© 2017 Doger de Speville, Robert, Perez-Guevara, Grigis, Bolle, Pinaud, Dufour, Beaudré, Kieffer, Longaud, Grill, Valteau-Couanet, Deutsch, Lefkopoulos, Chiron, Hertz-Pannier and Noulhiane.
PY - 2017/8/18
Y1 - 2017/8/18
N2 - Pediatric posterior fossa tumor (PFT) survivors who have been treated with cranial radiation therapy often suffer from cognitive impairments that might relate to IQ decline. Radiotherapy (RT) distinctly affects brain regions involved in different cognitive functions. However, the relative contribution of regional irradiation to the different cognitive impairments still remains unclear. We investigated the relationships between the changes in different cognitive scores and radiation dose distribution in 30 children treated for a PFT. Our exploratory analysis was based on a principal component analysis (PCA) and an ordinary least square regression approach. The use of a PCA was an innovative way to cluster correlated irradiated regions due to similar radiation therapy protocols across patients. Our results suggest an association between working memory decline and a high dose (equivalent uniform dose, EUD) delivered to the orbitofrontal regions, whereas the decline of processing speed seemed more related to EUD in the temporal lobes and posterior fossa. To identify regional effects of RT on cognitive functions may help to propose a rehabilitation program adapted to the risk of cognitive impairment.
AB - Pediatric posterior fossa tumor (PFT) survivors who have been treated with cranial radiation therapy often suffer from cognitive impairments that might relate to IQ decline. Radiotherapy (RT) distinctly affects brain regions involved in different cognitive functions. However, the relative contribution of regional irradiation to the different cognitive impairments still remains unclear. We investigated the relationships between the changes in different cognitive scores and radiation dose distribution in 30 children treated for a PFT. Our exploratory analysis was based on a principal component analysis (PCA) and an ordinary least square regression approach. The use of a PCA was an innovative way to cluster correlated irradiated regions due to similar radiation therapy protocols across patients. Our results suggest an association between working memory decline and a high dose (equivalent uniform dose, EUD) delivered to the orbitofrontal regions, whereas the decline of processing speed seemed more related to EUD in the temporal lobes and posterior fossa. To identify regional effects of RT on cognitive functions may help to propose a rehabilitation program adapted to the risk of cognitive impairment.
KW - Cognitive impairments
KW - Pediatric
KW - Posterior fossa
KW - Radiation effects
KW - Radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=85027848398&partnerID=8YFLogxK
U2 - 10.3389/fonc.2017.00166
DO - 10.3389/fonc.2017.00166
M3 - Article
AN - SCOPUS:85027848398
SN - 2234-943X
VL - 7
JO - Frontiers in Oncology
JF - Frontiers in Oncology
IS - AUG
M1 - 166
ER -