Reproducibility of glucose and insulin responses to mixed meal in type II diabetic patients

Objective: The reproducibility of glucose and insulin responses to a mixed meal were studied in 24 consecutive non-insulin-dependent (type II) diabetic patients, the diet of which matched the tested diet. Patients received their usual treatment throughout the study. Research Design and Methods: A standardized diet was followed for 3 days, and responses were measured on the 2nd and 3rd days. Glucose and insulin responses were studied after lunches with the 180-min positive area under the curve, and were analyzed with paired t test and Pearson's linear regression. Results: Glucose responses did not vary (217 ± 50 vs. 217 ± 38 min × mM, NS) and were significantly correlated (r = 0.64, P < 0.01). Insulin responses did not vary (35,224 ± 5768 vs. 35,305 ± 7779 min × pM, NS) and were strongly correlated (r = 0.83, P < 0.001). Conclusions: These results suggest that glucose and insulin responses to a test meal are reproducible in type II diabetic patients.