TY - JOUR
T1 - Role of Cardiac Imaging in the Diagnosis of Immune Checkpoints Inhibitors Related Myocarditis
AU - Ederhy, Stéphane
AU - Salem, Joe Elie
AU - Dercle, Laurent
AU - Hasan, Abrar Saqif
AU - Chauvet-Droit, Marion
AU - Nhan, Pascal
AU - Ammari, Samy
AU - Pinna, Bruno
AU - Redheuil, Alban
AU - Boussouar, Samia
AU - Champiat, Stephane
AU - Soulat-Dufour, Laurie
AU - Cohen, Ariel
N1 - Publisher Copyright:
© Copyright © 2021 Ederhy, Salem, Dercle, Hasan, Chauvet-Droit, Nhan, Ammari, Pinna, Redheuil, Boussouar, Champiat, Soulat-Dufour and Cohen.
PY - 2021/5/13
Y1 - 2021/5/13
N2 - Immune checkpoint inhibitors (ICI) have constituted a paradigm shift in the management of patients with cancer. Their administration is associated with a new spectrum of immune-related toxicities that can affect any organ. In patients treated with ICI, cardiovascular toxicities, particularly myocarditis, occur with a low incidence (<1%) but with a high fatality rate (30−50%). ICI-related myocarditis has been attributed to an immune infiltration, comprising of T-cells that are positive for CD3+, CD4+, CD8+, and macrophages that are positive for CD68. The diagnosis remains challenging and is made based on clinical syndrome, an electrocardiogram (ECG), biomarker data, and imaging criteria. In most clinical scenarios, endomyocardial biopsy plays a pivotal role in diagnosis, while cardiac magnetic resonance imaging (cMRI) has limitations that should be acknowledged. In this review, we discuss the role of medical imaging in optimizing the management of ICI related myocarditis, including diagnosis, prognostication, and treatment decisions.
AB - Immune checkpoint inhibitors (ICI) have constituted a paradigm shift in the management of patients with cancer. Their administration is associated with a new spectrum of immune-related toxicities that can affect any organ. In patients treated with ICI, cardiovascular toxicities, particularly myocarditis, occur with a low incidence (<1%) but with a high fatality rate (30−50%). ICI-related myocarditis has been attributed to an immune infiltration, comprising of T-cells that are positive for CD3+, CD4+, CD8+, and macrophages that are positive for CD68. The diagnosis remains challenging and is made based on clinical syndrome, an electrocardiogram (ECG), biomarker data, and imaging criteria. In most clinical scenarios, endomyocardial biopsy plays a pivotal role in diagnosis, while cardiac magnetic resonance imaging (cMRI) has limitations that should be acknowledged. In this review, we discuss the role of medical imaging in optimizing the management of ICI related myocarditis, including diagnosis, prognostication, and treatment decisions.
KW - cancer
KW - cardiac magnetic resonance imaging
KW - cardiotoxicity
KW - immune checkpoint inhibitor
KW - myocarditis
UR - http://www.scopus.com/inward/record.url?scp=85107073741&partnerID=8YFLogxK
U2 - 10.3389/fonc.2021.640985
DO - 10.3389/fonc.2021.640985
M3 - Review article
AN - SCOPUS:85107073741
SN - 2234-943X
VL - 11
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 640985
ER -