Role of meta-analyses and of large randomized trials in the study of cancer treatments

Jean Pierre Pignon; Anne Auperin; Isabelle Borget; Catherine Hill

doi:10.1016/j.lungcan.2008.10.017

Role of meta-analyses and of large randomized trials in the study of cancer treatments

Jean Pierre Pignon, Anne Auperin, Isabelle Borget, Catherine Hill

Résultats de recherche: Contribution à un journal › Article 'review' › Revue par des pairs

8 Citations (Scopus)

Résumé

The paper contributes to the discussion on the usefulness of meta-analysis as compared to large scale trial. After reviewing the issues to consider when comparing the results of a meta-analysis and of a large trial, several examples, in particular in thoracic oncology, of complementary uses of meta-analysis and large trials are discussed. Three types of examples are presented: (a) trial designed to confirm the overall results of a meta-analysis; (b) trial designed to confirm an interaction between a covariate and the treatment effect detected in a meta-analysis; (c) trial designed to confirm an interaction between a treatment parameter and the treatment effect detected in a meta-analysis. In conclusion, well-conducted meta-analyses and large trials are complementary tools to evaluate new treatments.

langue originale	Anglais
Pages (de - à)	9-12
Nombre de pages	4
journal	Lung Cancer
Volume	65
Numéro de publication	1
Les DOIs	https://doi.org/10.1016/j.lungcan.2008.10.017
état	Publié - 1 juil. 2009

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10.1016/j.lungcan.2008.10.017

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title = "Role of meta-analyses and of large randomized trials in the study of cancer treatments",

abstract = "The paper contributes to the discussion on the usefulness of meta-analysis as compared to large scale trial. After reviewing the issues to consider when comparing the results of a meta-analysis and of a large trial, several examples, in particular in thoracic oncology, of complementary uses of meta-analysis and large trials are discussed. Three types of examples are presented: (a) trial designed to confirm the overall results of a meta-analysis; (b) trial designed to confirm an interaction between a covariate and the treatment effect detected in a meta-analysis; (c) trial designed to confirm an interaction between a treatment parameter and the treatment effect detected in a meta-analysis. In conclusion, well-conducted meta-analyses and large trials are complementary tools to evaluate new treatments.",

keywords = "Chemotherapy, Individual patient data, Large scale trial, Lung cancer, Meta-analysis, Quality of meta-analysis, Radiotherapy, Randomized trials",

author = "Pignon, {Jean Pierre} and Anne Auperin and Isabelle Borget and Catherine Hill",

note = "Funding Information: We thanks Pr Rodrigo Arriagada for his fruitful comments. Supported by a grant of the Ligue Nationale Contre le Cancer.",

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AU - Pignon, Jean Pierre

AU - Auperin, Anne

AU - Borget, Isabelle

AU - Hill, Catherine

N1 - Funding Information: We thanks Pr Rodrigo Arriagada for his fruitful comments. Supported by a grant of the Ligue Nationale Contre le Cancer.

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AB - The paper contributes to the discussion on the usefulness of meta-analysis as compared to large scale trial. After reviewing the issues to consider when comparing the results of a meta-analysis and of a large trial, several examples, in particular in thoracic oncology, of complementary uses of meta-analysis and large trials are discussed. Three types of examples are presented: (a) trial designed to confirm the overall results of a meta-analysis; (b) trial designed to confirm an interaction between a covariate and the treatment effect detected in a meta-analysis; (c) trial designed to confirm an interaction between a treatment parameter and the treatment effect detected in a meta-analysis. In conclusion, well-conducted meta-analyses and large trials are complementary tools to evaluate new treatments.

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KW - Individual patient data

KW - Large scale trial

KW - Lung cancer

KW - Meta-analysis

KW - Quality of meta-analysis

KW - Radiotherapy

KW - Randomized trials

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