TY - JOUR
T1 - Safeguarding DNA Replication
T2 - A Golden Touch of MiDAS and Other Mechanisms
AU - Al Ahmad Nachar, Baraah
AU - Rosselli, Filippo
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/10/1
Y1 - 2022/10/1
N2 - DNA replication is a tightly regulated fundamental process allowing the correct duplication and transfer of the genetic information from the parental cell to the progeny. It involves the coordinated assembly of several proteins and protein complexes resulting in replication fork licensing, firing and progression. However, the DNA replication pathway is strewn with hurdles that affect replication fork progression during S phase. As a result, cells have adapted several mechanisms ensuring replication completion before entry into mitosis and segregating chromosomes with minimal, if any, abnormalities. In this review, we describe the possible obstacles that a replication fork might encounter and how the cell manages to protect DNA replication from S to the next G1.
AB - DNA replication is a tightly regulated fundamental process allowing the correct duplication and transfer of the genetic information from the parental cell to the progeny. It involves the coordinated assembly of several proteins and protein complexes resulting in replication fork licensing, firing and progression. However, the DNA replication pathway is strewn with hurdles that affect replication fork progression during S phase. As a result, cells have adapted several mechanisms ensuring replication completion before entry into mitosis and segregating chromosomes with minimal, if any, abnormalities. In this review, we describe the possible obstacles that a replication fork might encounter and how the cell manages to protect DNA replication from S to the next G1.
KW - chromosome instability
KW - DNA repair
KW - DNA replication
KW - FANCD2
KW - MiDAS
UR - http://www.scopus.com/inward/record.url?scp=85139947565&partnerID=8YFLogxK
U2 - 10.3390/ijms231911331
DO - 10.3390/ijms231911331
M3 - Review article
C2 - 36232633
AN - SCOPUS:85139947565
SN - 1661-6596
VL - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 19
M1 - 11331
ER -