Safeguarding DNA Replication: A Golden Touch of MiDAS and Other Mechanisms

Baraah Al Ahmad Nachar, Filippo Rosselli

Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

1 Citation (Scopus)

Résumé

DNA replication is a tightly regulated fundamental process allowing the correct duplication and transfer of the genetic information from the parental cell to the progeny. It involves the coordinated assembly of several proteins and protein complexes resulting in replication fork licensing, firing and progression. However, the DNA replication pathway is strewn with hurdles that affect replication fork progression during S phase. As a result, cells have adapted several mechanisms ensuring replication completion before entry into mitosis and segregating chromosomes with minimal, if any, abnormalities. In this review, we describe the possible obstacles that a replication fork might encounter and how the cell manages to protect DNA replication from S to the next G1.

langue originaleAnglais
Numéro d'article11331
journalInternational Journal of Molecular Sciences
Volume23
Numéro de publication19
Les DOIs
étatPublié - 1 oct. 2022
Modification externeOui

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