Salvage Therapy with Bevacizumab-Sunitinib Combination after Failure of Sunitinib Alone for Metastatic Renal Cell Carcinoma: A Case Series

Jacques Medioni; Eugeniu Banu; Dominique Helley; Florian Scotte; Laure Fournier; Arnaud Mejean; Antoine Chedid; Michel Azizi; Jean Marie Andrieu; Stéphane Oudard

doi:10.1016/j.eururo.2009.01.001

Salvage Therapy with Bevacizumab-Sunitinib Combination after Failure of Sunitinib Alone for Metastatic Renal Cell Carcinoma: A Case Series

Jacques Medioni, Eugeniu Banu, Dominique Helley, Florian Scotte, Laure Fournier, Arnaud Mejean, Antoine Chedid, Michel Azizi, Jean Marie Andrieu, Stéphane Oudard

Résultats de recherche: Contribution à un journal › Brève enquête › Revue par des pairs

18 Citations (Scopus)

Résumé

We present a case series of seven patients with metastatic renal cell carcinoma treated with bevacizumab (10 mg/kg) in combination with sunitinib 25-50 mg as salvage therapy after disease progression under sunitinib monotherapy. Two patients had a partial response, four had stable disease, and one patient had disease progression. After a median follow-up of 17.2 mo, median progression-free survival and overall survival were 8.5 and 15.1 mo, respectively. Two patients experienced exacerbation of their preexisting hypertension; there were no grade 4 toxicities. The bevacizumab-sunitinib combination in sunitinib-refractory patients seems active and has a tolerable toxicity profile. Crown

langue originale	Anglais
Pages (de - à)	207-211
Nombre de pages	5
journal	European Urology
Volume	56
Numéro de publication	1
Les DOIs	https://doi.org/10.1016/j.eururo.2009.01.001
état	Publié - 1 juil. 2009
Modification externe	Oui

Accès au document

10.1016/j.eururo.2009.01.001

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title = "Salvage Therapy with Bevacizumab-Sunitinib Combination after Failure of Sunitinib Alone for Metastatic Renal Cell Carcinoma: A Case Series",

abstract = "We present a case series of seven patients with metastatic renal cell carcinoma treated with bevacizumab (10 mg/kg) in combination with sunitinib 25-50 mg as salvage therapy after disease progression under sunitinib monotherapy. Two patients had a partial response, four had stable disease, and one patient had disease progression. After a median follow-up of 17.2 mo, median progression-free survival and overall survival were 8.5 and 15.1 mo, respectively. Two patients experienced exacerbation of their preexisting hypertension; there were no grade 4 toxicities. The bevacizumab-sunitinib combination in sunitinib-refractory patients seems active and has a tolerable toxicity profile. Crown",

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T2 - A Case Series

AU - Medioni, Jacques

AU - Banu, Eugeniu

AU - Helley, Dominique

AU - Scotte, Florian

AU - Fournier, Laure

AU - Mejean, Arnaud

AU - Chedid, Antoine

AU - Azizi, Michel

AU - Andrieu, Jean Marie

AU - Oudard, Stéphane

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AB - We present a case series of seven patients with metastatic renal cell carcinoma treated with bevacizumab (10 mg/kg) in combination with sunitinib 25-50 mg as salvage therapy after disease progression under sunitinib monotherapy. Two patients had a partial response, four had stable disease, and one patient had disease progression. After a median follow-up of 17.2 mo, median progression-free survival and overall survival were 8.5 and 15.1 mo, respectively. Two patients experienced exacerbation of their preexisting hypertension; there were no grade 4 toxicities. The bevacizumab-sunitinib combination in sunitinib-refractory patients seems active and has a tolerable toxicity profile. Crown

KW - Bevacizumab

KW - Renal cell carcinoma

KW - Salvage therapy

KW - Sunitinib

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