TY - JOUR
T1 - Second to fourth digit ratio (2D:4D) and prostate cancer risk in the Melbourne Collaborative Cohort Study
AU - Muller, D. C.
AU - Giles, G. G.
AU - Manning, J. T.
AU - Hopper, J. L.
AU - English, D. R.
AU - Severi, G.
PY - 2011/7/26
Y1 - 2011/7/26
N2 - Background: The ratio of the lengths of index and ring fingers (2D:4D) is a marker of prenatal exposure to sex hormones, with low 2D:4D being indicative of high prenatal androgen action. Recent studies have reported a strong association between 2D:4D and risk of prostate cancer.Methods:A total of 6258 men participating in the Melbourne Collaborative Cohort Study had 2D:4D assessed. Of these men, we identified 686 incident prostate cancer cases. Hazard ratios (HRs) and confidence intervals (CIs) were estimated for a standard deviation increase in 2D:4D.Results:No association was observed between 2D:4D and prostate cancer risk overall (HRs 1.00; 95% CIs, 0.92-1.08 for right, 0.93-1.08 for left). We observed a weak inverse association between 2D:4D and risk of prostate cancer for age 60, however 95% CIs included unity for all observed ages. Conclusion: Our results are not consistent with an association between 2D:4D and overall prostate cancer risk, but we cannot exclude a weak inverse association between 2D:4D and early onset prostate cancer risk.
AB - Background: The ratio of the lengths of index and ring fingers (2D:4D) is a marker of prenatal exposure to sex hormones, with low 2D:4D being indicative of high prenatal androgen action. Recent studies have reported a strong association between 2D:4D and risk of prostate cancer.Methods:A total of 6258 men participating in the Melbourne Collaborative Cohort Study had 2D:4D assessed. Of these men, we identified 686 incident prostate cancer cases. Hazard ratios (HRs) and confidence intervals (CIs) were estimated for a standard deviation increase in 2D:4D.Results:No association was observed between 2D:4D and prostate cancer risk overall (HRs 1.00; 95% CIs, 0.92-1.08 for right, 0.93-1.08 for left). We observed a weak inverse association between 2D:4D and risk of prostate cancer for age 60, however 95% CIs included unity for all observed ages. Conclusion: Our results are not consistent with an association between 2D:4D and overall prostate cancer risk, but we cannot exclude a weak inverse association between 2D:4D and early onset prostate cancer risk.
UR - http://www.scopus.com/inward/record.url?scp=79960844173&partnerID=8YFLogxK
U2 - 10.1038/bjc.2011.253
DO - 10.1038/bjc.2011.253
M3 - Article
C2 - 21730975
AN - SCOPUS:79960844173
SN - 0007-0920
VL - 105
SP - 438
EP - 440
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 3
ER -