Secondary Necrosis: Accidental No More

Lorenzo Galluzzi; Guido Kroemer

doi:10.1016/j.trecan.2016.12.001

Secondary Necrosis: Accidental No More

Lorenzo Galluzzi, Guido Kroemer

Résultats de recherche: Contribution à un journal › Brève enquête › Revue par des pairs

26 Citations (Scopus)

Résumé

Recent data demonstrate that secondary necrosis is not an accidental epiphenomenon of apoptosis, but a finely regulated process with prominent pathophysiological and therapeutic implications. The molecular machinery that controls secondary necrosis stands out as a promising target for the development of novel drugs that may increase the immunogenicity of cancer cells succumbing to treatment.

langue originale	Anglais
Pages (de - à)	1-2
Nombre de pages	2
journal	Trends in Cancer
Volume	3
Numéro de publication	1
Les DOIs	https://doi.org/10.1016/j.trecan.2016.12.001
état	Publié - 1 janv. 2017

Accès au document

10.1016/j.trecan.2016.12.001

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title = "Secondary Necrosis: Accidental No More",

abstract = "Recent data demonstrate that secondary necrosis is not an accidental epiphenomenon of apoptosis, but a finely regulated process with prominent pathophysiological and therapeutic implications. The molecular machinery that controls secondary necrosis stands out as a promising target for the development of novel drugs that may increase the immunogenicity of cancer cells succumbing to treatment.",

keywords = "DFNA5, GSDMD, caspases, danger signaling, necroptosis, pyroptosis",

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