Seconde laparotomie negative dans les cancers de l'ovaire. Analyse de la survie et des facteurs pronostiques a partir de 64 cas traites a l'Institut Gustave-Roussy

Patricia Pautier, Annie Rey, Guy Michel, Damiène Castaigne, France Rochard, Pierre Duvillard, Christine Haie-Meder, Patricia Curcio, Laurence Benedetti-Richard, Catherine Lhommé

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    5 Citations (Scopus)

    Résumé

    This study describes 64 cases of ovarian adenocarcinoma seen in the Gustave-Roussy Institut between 1978 and 1988 and who had a negative second-look laparotomy. The median age was 51 years (30-74). FIGO stages were: I: 7 (11%). II: 3 (5%); III: 39 (61%); IV: 3 (5%); and undetermined: 12 (19%). There were 53% of serous type, 14% of endometrioid type, 13% of undifferentiated type, 8% of clear cells type, 3% of mucinous type, and 9% of mixt type tumors. There were 50% of grade 3 tumors. Initial debulking surgery was as complete as possible in 59 patients, with a residual tumor afer surgery superior or equal to 2 cm in 25 patients. Post second-look surgery treatment (n = 57) consisted of chemotherapy (CT) alone in 22 patients (34%), radiotherapy (RT) alone in 31 patients (49%), and CT associated with RT in 4 patients (6%). Median follow-up is 100 months. The overall survival rates at 3 and 5 years were respectively 86 and 81%, and disease free survival rates 70 and 61%. Among the 64 patients, 26 relapsed (39%). Median time to relapse was 96 months. There is a statistical difference in the survival between patients who had no or inferior to 2 cm residual tumor and others. Residual tumor was the only factor to be significant in univariate and multivariate analysis of survival.

    Titre traduit de la contributionNegative second-look laparotomy: An ovarian cancer analysis of prognostic and survival factors based on 64 cases treated at the Institut Gustave-Roussy
    langue originaleFrançais
    Pages (de - à)147-154
    Nombre de pages8
    journalBulletin du Cancer
    Volume84
    Numéro de publication2
    étatPublié - 1 janv. 1997

    mots-clés

    • negative second-look laparotomy
    • ovarian adenocarcinoma
    • prognosis

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