Seeking Cellular Fitness and Immune Evasion: Autophagy in Pancreatic Carcinoma

Guido Kroemer; Laurence Zitvogel

doi:10.1016/j.ccell.2020.05.009

Seeking Cellular Fitness and Immune Evasion: Autophagy in Pancreatic Carcinoma

Guido Kroemer, Laurence Zitvogel

Résultats de recherche: Contribution à un journal › !!Comment/debate

7 Citations (Scopus)

Résumé

In a recent Nature paper, Yamamoto et al. demonstrate that, in the particular context of pancreatic carcinoma, autophagy causes the continuous destruction of major histocompatibility complex class I (MHC-I) proteins. Suppression of autophagy favors MHC-I re-appearance on the surface of malignant cells, facilitating their clearance by cytotoxic T lymphocytes.

langue originale	Anglais
Pages (de - à)	759-760
Nombre de pages	2
journal	Cancer Cell
Volume	37
Numéro de publication	6
Les DOIs	https://doi.org/10.1016/j.ccell.2020.05.009
état	Publié - 8 juin 2020

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10.1016/j.ccell.2020.05.009

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title = "Seeking Cellular Fitness and Immune Evasion: Autophagy in Pancreatic Carcinoma",

abstract = "In a recent Nature paper, Yamamoto et al. demonstrate that, in the particular context of pancreatic carcinoma, autophagy causes the continuous destruction of major histocompatibility complex class I (MHC-I) proteins. Suppression of autophagy favors MHC-I re-appearance on the surface of malignant cells, facilitating their clearance by cytotoxic T lymphocytes.",

author = "Guido Kroemer and Laurence Zitvogel",

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AU - Zitvogel, Laurence

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AB - In a recent Nature paper, Yamamoto et al. demonstrate that, in the particular context of pancreatic carcinoma, autophagy causes the continuous destruction of major histocompatibility complex class I (MHC-I) proteins. Suppression of autophagy favors MHC-I re-appearance on the surface of malignant cells, facilitating their clearance by cytotoxic T lymphocytes.

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M3 - Comment/debate

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