Sentinel lymph node biopsy in head and neck oncology

Titre traduit de la contribution: Place et modalités des indications de recherche du ganglion sentinelle dans les tumeurs de la tête et du cou

Antoine Moya-Plana, Joanne Guerlain, Odile Casiraghi, François Bidault, Séréna Grimaldi, Ingrid Breuskin, Philippe Gorphe, Stéphane Temam

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    4 Citations (Scopus)

    Résumé

    Sentinel lymph node biopsy (SLNB) has been initially developed for melanoma and breast cancers. Its application in head and neck cancers is recent, probably due to the complexity of the lymphatic drainage, the proximity between the primary tumor and the lymph nodes and the critical anatomical structures (such as the facial nerve). In onco-dermatology, SLNB is validated in head and neck surgery for melanoma with Breslow thickness up to 1 mm or ulceration, Merkel carcinoma and high-risk squamous cell carcinoma. Considering the malignancies of the upper aerodigestive tract, the feasibility and oncologic safety of SLNB are now established for T1-T2N0 oral and oropharyngeal squamous cell carcinomas. Thus, it could allow patients with negative sentinel nodes to avoid an unnecessary neck dissection, leading to a decrease of morbidity with an quality of life improvement. For some primary locations (e.g., anterior floor of the mouth) with high proximity between tumor and lymph nodes, it is recommended to remove the tumor before the SLNB so as to improve the detection. New techniques of detection are currently being developed with intra-operative procedures and new tracers (such as tilmanocept), leading to a better accuracy of detection and, probably, new indications.

    Titre traduit de la contributionPlace et modalités des indications de recherche du ganglion sentinelle dans les tumeurs de la tête et du cou
    langue originaleAnglais
    Pages (de - à)653-659
    Nombre de pages7
    journalBulletin du Cancer
    Volume107
    Numéro de publication6
    Les DOIs
    étatPublié - 1 juin 2020

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