Smoking and papillomavirus DNA in patients with p16-positive N3 oropharyngeal squamous cell carcinoma

Philippe Gorphe; Younes Chekkoury Idrissi; Yungan Tao; Antoine Moya-Plana; Odile Casiraghi; François Janot; Pierre Blanchard; Haïtham Mirghani; Stéphane Temam

doi:10.1002/hed.25523

Smoking and papillomavirus DNA in patients with p16-positive N3 oropharyngeal squamous cell carcinoma

Philippe Gorphe, Younes Chekkoury Idrissi, Yungan Tao, Antoine Moya-Plana, Odile Casiraghi, François Janot, Pierre Blanchard, Haïtham Mirghani, Stéphane Temam

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

3 Citations (Scopus)

Résumé

Background: We investigated the survival of patients with a p16-positive N3 oropharyngeal squamous cell carcinoma (OPSCC) and the prognostic significance of patient, tumor, and treatment characteristics. Methods: We retrospectively reviewed the data of patients treated at our Cancer Center for a p16-positive N3 OPSCC between 2003 and 2016. End points were overall survival (OS) and progression-free survival (PFS). Results: A total of 29 patients were included. The 5-year OS and PFS were 67.5% and 59.1%, respectively. Smoking history above 10 pack-years and the absence of human papillomavirus DNA were associated with worse OS (P =.02 and P =.03, respectively) and PFS (P =.02 and P =.02, respectively). Induction chemotherapy or radical neck dissection were not associated with different treatment outcomes. Conclusion: Patients with an N3 p16-positive oropharyngeal cancer in our series had a 5-year OS rate of 67.5%. Smoking history and viral DNA were prognostic factors associated with survival.

langue originale	Anglais
Pages (de - à)	1039-1045
Nombre de pages	7
journal	Head and Neck
Volume	41
Numéro de publication	4
Les DOIs	https://doi.org/10.1002/hed.25523
état	Publié - 1 avr. 2019

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10.1002/hed.25523

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@article{657c42f50762477ea474dffaeadfc86d,

title = "Smoking and papillomavirus DNA in patients with p16-positive N3 oropharyngeal squamous cell carcinoma",

abstract = "Background: We investigated the survival of patients with a p16-positive N3 oropharyngeal squamous cell carcinoma (OPSCC) and the prognostic significance of patient, tumor, and treatment characteristics. Methods: We retrospectively reviewed the data of patients treated at our Cancer Center for a p16-positive N3 OPSCC between 2003 and 2016. End points were overall survival (OS) and progression-free survival (PFS). Results: A total of 29 patients were included. The 5-year OS and PFS were 67.5% and 59.1%, respectively. Smoking history above 10 pack-years and the absence of human papillomavirus DNA were associated with worse OS (P =.02 and P =.03, respectively) and PFS (P =.02 and P =.02, respectively). Induction chemotherapy or radical neck dissection were not associated with different treatment outcomes. Conclusion: Patients with an N3 p16-positive oropharyngeal cancer in our series had a 5-year OS rate of 67.5%. Smoking history and viral DNA were prognostic factors associated with survival.",

keywords = "N3, human papillomavirus, oropharyngeal neoplasms, p16 immunohistochemistry, smoking history",

author = "Philippe Gorphe and {Chekkoury Idrissi}, Younes and Yungan Tao and Antoine Moya-Plana and Odile Casiraghi and Fran{\c c}ois Janot and Pierre Blanchard and Ha{\"i}tham Mirghani and St{\'e}phane Temam",

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year = "2019",

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day = "1",

doi = "10.1002/hed.25523",

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TY - JOUR

T1 - Smoking and papillomavirus DNA in patients with p16-positive N3 oropharyngeal squamous cell carcinoma

AU - Gorphe, Philippe

AU - Chekkoury Idrissi, Younes

AU - Tao, Yungan

AU - Moya-Plana, Antoine

AU - Casiraghi, Odile

AU - Janot, François

AU - Blanchard, Pierre

AU - Mirghani, Haïtham

AU - Temam, Stéphane

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Background: We investigated the survival of patients with a p16-positive N3 oropharyngeal squamous cell carcinoma (OPSCC) and the prognostic significance of patient, tumor, and treatment characteristics. Methods: We retrospectively reviewed the data of patients treated at our Cancer Center for a p16-positive N3 OPSCC between 2003 and 2016. End points were overall survival (OS) and progression-free survival (PFS). Results: A total of 29 patients were included. The 5-year OS and PFS were 67.5% and 59.1%, respectively. Smoking history above 10 pack-years and the absence of human papillomavirus DNA were associated with worse OS (P =.02 and P =.03, respectively) and PFS (P =.02 and P =.02, respectively). Induction chemotherapy or radical neck dissection were not associated with different treatment outcomes. Conclusion: Patients with an N3 p16-positive oropharyngeal cancer in our series had a 5-year OS rate of 67.5%. Smoking history and viral DNA were prognostic factors associated with survival.

AB - Background: We investigated the survival of patients with a p16-positive N3 oropharyngeal squamous cell carcinoma (OPSCC) and the prognostic significance of patient, tumor, and treatment characteristics. Methods: We retrospectively reviewed the data of patients treated at our Cancer Center for a p16-positive N3 OPSCC between 2003 and 2016. End points were overall survival (OS) and progression-free survival (PFS). Results: A total of 29 patients were included. The 5-year OS and PFS were 67.5% and 59.1%, respectively. Smoking history above 10 pack-years and the absence of human papillomavirus DNA were associated with worse OS (P =.02 and P =.03, respectively) and PFS (P =.02 and P =.02, respectively). Induction chemotherapy or radical neck dissection were not associated with different treatment outcomes. Conclusion: Patients with an N3 p16-positive oropharyngeal cancer in our series had a 5-year OS rate of 67.5%. Smoking history and viral DNA were prognostic factors associated with survival.

KW - N3

KW - human papillomavirus

KW - oropharyngeal neoplasms

KW - p16 immunohistochemistry

KW - smoking history

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