TY - JOUR
T1 - Solid malignant neoplasms after childhood irradiation
T2 - Decrease of the relative risk with time after irradiation
AU - De Vathaire, F.
AU - Shamsaldin, A.
AU - Grimaud, E.
AU - Campbell, S.
AU - Guerra, M.
AU - Raquin, M.
AU - Bessa, E.
AU - Hardiman, C.
AU - Jan, P.
AU - Rumeau, N.
AU - Diallo, I.
AU - Nicolazic, G.
AU - Lamon, A.
AU - Oberlin, O.
AU - De Cervens, C.
AU - Suarez, A.
AU - Meresse, V.
AU - Hawkins, M.
AU - Bell, J.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - The pattern of he temporal distribution of solid cancer incidence after irradiation in childhood is not well known, although, its importance in radioprotection is well known. We studied a cohort of 1,055 children from 8 European cancer centres, who received radiotherapy between 1942 and 1985 for a first cancer in childhood. After a mean follow-tip of 19 years, 26 children developed a solid second malignant neoplasm (SMN), as compared to 5.6 expected from general population rates. Both the excess relative risk and the excess of absolute risk of solid SMN were higher among children who were younger at time of the irradiation. After reaching a maximum 15 to 20 years after irradiation, the excess relative risk of SMN decreased with time after irradiation, when controlling for age at irradiation and sex. The analysis of the risk of thyroid, brain and breast cancer together, as a function of the dose averaged on these 3 organs lead to similar results.
AB - The pattern of he temporal distribution of solid cancer incidence after irradiation in childhood is not well known, although, its importance in radioprotection is well known. We studied a cohort of 1,055 children from 8 European cancer centres, who received radiotherapy between 1942 and 1985 for a first cancer in childhood. After a mean follow-tip of 19 years, 26 children developed a solid second malignant neoplasm (SMN), as compared to 5.6 expected from general population rates. Both the excess relative risk and the excess of absolute risk of solid SMN were higher among children who were younger at time of the irradiation. After reaching a maximum 15 to 20 years after irradiation, the excess relative risk of SMN decreased with time after irradiation, when controlling for age at irradiation and sex. The analysis of the risk of thyroid, brain and breast cancer together, as a function of the dose averaged on these 3 organs lead to similar results.
KW - Childhood
KW - Radiocarcinogenesis
KW - Radioprotection
UR - http://www.scopus.com/inward/record.url?scp=0029031425&partnerID=8YFLogxK
M3 - Article
C2 - 7648361
AN - SCOPUS:0029031425
SN - 0764-4469
VL - 318
SP - 483
EP - 490
JO - Comptes Rendus de l'Academie des Sciences - Serie III
JF - Comptes Rendus de l'Academie des Sciences - Serie III
IS - 4
ER -