TY - JOUR
T1 - Soluble intercellular adhesion molecule 1 in umbilical cord serum
T2 - Potential for the diagnosis of neonatal infections
AU - Daraï, Emile
AU - Poncelet, Christophe
AU - Soriano, David
AU - Lejeune, Veronique
AU - Bringuier, Annie France
AU - Madelenat, Patrick
AU - Feldmann, Gerard
AU - Scoazec, Jean Yves
PY - 2002/4/6
Y1 - 2002/4/6
N2 - Objective: To evaluate the diagnostic relevance to neonatal infections of the soluble intercellular adhesion molecule 1 (sICAM-1) cord serum level. Methods: The case-control study included 66 term newborn infants with and without risk factors for neonatal infections. Cord blood serum determinations of white blood cell count, C-reactive protein, fibrinogen, and sICAM-1 were systematically performed associated with bacterial cultures from placenta, ears, and gastric fluids. Results: 6 of 33 infants (18.2%) with risk factors were infected, and 13 (39.4%) were colonized. Two infants included in the group without infection risk factors (n = 33) were colonized. No difference in sICAM-1 cord serum levels was found according to the presence of premature rupture of membrane, fetal tachycardia > 1160 bpm, meconial amniotic fluid, and duration of labour > 110 h. No difference in sICAM-1 was noted between infected and non-infected infants. The cord serum levels of sICAM-1 were significantly higher in infants after forceps extraction (p = 0.01). A correlation was observed between sICAM-1 and C-reactive protein cord serum levels (p = 0.004, r = 0.371) and between sICAM-1 level and neutrophil count (p = 0.01, r = 0.489). Conclusions: Our results suggest that cord serum sICAM-1 determinations have no diagnostic relevance to neonatal infection. The increase of sICAM-1 cord serum levels in infants after forceps extraction suggests its potential to evaluate cerebral trauma or hypoxia.
AB - Objective: To evaluate the diagnostic relevance to neonatal infections of the soluble intercellular adhesion molecule 1 (sICAM-1) cord serum level. Methods: The case-control study included 66 term newborn infants with and without risk factors for neonatal infections. Cord blood serum determinations of white blood cell count, C-reactive protein, fibrinogen, and sICAM-1 were systematically performed associated with bacterial cultures from placenta, ears, and gastric fluids. Results: 6 of 33 infants (18.2%) with risk factors were infected, and 13 (39.4%) were colonized. Two infants included in the group without infection risk factors (n = 33) were colonized. No difference in sICAM-1 cord serum levels was found according to the presence of premature rupture of membrane, fetal tachycardia > 1160 bpm, meconial amniotic fluid, and duration of labour > 110 h. No difference in sICAM-1 was noted between infected and non-infected infants. The cord serum levels of sICAM-1 were significantly higher in infants after forceps extraction (p = 0.01). A correlation was observed between sICAM-1 and C-reactive protein cord serum levels (p = 0.004, r = 0.371) and between sICAM-1 level and neutrophil count (p = 0.01, r = 0.489). Conclusions: Our results suggest that cord serum sICAM-1 determinations have no diagnostic relevance to neonatal infection. The increase of sICAM-1 cord serum levels in infants after forceps extraction suggests its potential to evaluate cerebral trauma or hypoxia.
KW - C-reactive protein
KW - Fibrinogen
KW - Neonatal infections
KW - Soluble intercellular adhesion molecule 1
UR - http://www.scopus.com/inward/record.url?scp=0036204321&partnerID=8YFLogxK
U2 - 10.1159/000048032
DO - 10.1159/000048032
M3 - Article
C2 - 11914570
AN - SCOPUS:0036204321
SN - 1015-3837
VL - 17
SP - 167
EP - 172
JO - Fetal Diagnosis and Therapy
JF - Fetal Diagnosis and Therapy
IS - 3
ER -