TY - JOUR
T1 - Soluble MICA-NKG2D interaction upregulates IFN-γ production by activated CD3-CD56+ NK cells
T2 - Potential impact on chronic graft versus host disease
AU - Boukouaci, Wahid
AU - Al-Daccak, Reem
AU - Dulphy, Nicolas
AU - Lauden, Laura
AU - Amokrane, Kahina
AU - Fortier, Catherine
AU - Marzais, François
AU - Bennabi, Meriem
AU - Peffault de Latour, Regis
AU - Socie, Gerard
AU - Toubert, Antoine
AU - Charron, Dominique
AU - Krishnamoorthy, Rajagopal
AU - Tamouza, Ryad
PY - 2013/10/4
Y1 - 2013/10/4
N2 - A soluble isoform of MHC class I chain-related molecule A (soluble MICA), generated by proteolytic shedding from the membrane-bound MICA of various tumor cells, has been shown to downregulate both the expression of natural killer group 2-member D receptor and the cytotoxic function of effectors cells and was postulated as a mechanism for tumor immune evasion. Its effect on the expression of cytokines by the effector cells remained unexplored. Here we demonstrate that the sMICA molecules upregulate interferon gamma expression by interleukin-12/interleukin-18-activated CD3-CD56+ natural killer cells, witnessing the pro-inflammatory effect of soluble MICA. Overall, these data are in line with our previous observations that the raised serum levels of soluble MICA, following allogeneic hematopoietic stem cell transplantation, confer susceptibility to and the presence of pre-transplantation anti-MICA antibodies in the patient's serum confer protection against chronic graft versus host disease.
AB - A soluble isoform of MHC class I chain-related molecule A (soluble MICA), generated by proteolytic shedding from the membrane-bound MICA of various tumor cells, has been shown to downregulate both the expression of natural killer group 2-member D receptor and the cytotoxic function of effectors cells and was postulated as a mechanism for tumor immune evasion. Its effect on the expression of cytokines by the effector cells remained unexplored. Here we demonstrate that the sMICA molecules upregulate interferon gamma expression by interleukin-12/interleukin-18-activated CD3-CD56+ natural killer cells, witnessing the pro-inflammatory effect of soluble MICA. Overall, these data are in line with our previous observations that the raised serum levels of soluble MICA, following allogeneic hematopoietic stem cell transplantation, confer susceptibility to and the presence of pre-transplantation anti-MICA antibodies in the patient's serum confer protection against chronic graft versus host disease.
UR - http://www.scopus.com/inward/record.url?scp=84888197387&partnerID=8YFLogxK
U2 - 10.1016/j.humimm.2013.08.281
DO - 10.1016/j.humimm.2013.08.281
M3 - Article
C2 - 23994587
AN - SCOPUS:84888197387
SN - 0198-8859
VL - 74
SP - 1536
EP - 1541
JO - Human Immunology
JF - Human Immunology
IS - 12
ER -