Spectral and spatial shaping of a laser-produced ion beam for radiation-biology experiments

L. Pommarel; B. Vauzour; F. Mégnin-Chanet; E. Bayart; O. Delmas; F. Goudjil; C. Nauraye; V. Letellier; F. Pouzoulet; F. Schillaci; F. Romano; V. Scuderi; G. A.P. Cirrone; E. Deutsch; A. Flacco; V. Malka

doi:10.1103/PhysRevAccelBeams.20.032801

Spectral and spatial shaping of a laser-produced ion beam for radiation-biology experiments

L. Pommarel, B. Vauzour, F. Mégnin-Chanet, E. Bayart, O. Delmas, F. Goudjil, C. Nauraye, V. Letellier, F. Pouzoulet, F. Schillaci, F. Romano, V. Scuderi, G. A.P. Cirrone, E. Deutsch, A. Flacco, V. Malka

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41 Citations (Scopus)

Résumé

The study of radiation biology on laser-based accelerators is most interesting due to the unique irradiation conditions they can produce, in terms of peak current and duration of the irradiation. In this paper we present the implementation of a beam transport system to transport and shape the proton beam generated by laser-target interaction for in vitro irradiation of biological samples. A set of four permanent magnet quadrupoles is used to transport and focus the beam, efficiently shaping the spectrum and providing a large and relatively uniform irradiation surface. Real time, absolutely calibrated, dosimetry is installed on the beam line, to enable shot-to-shot control of dose deposition in the irradiated volume. Preliminary results of cell sample irradiation are presented to validate the robustness of the full system.

langue originale	Anglais
Numéro d'article	032801
journal	Physical Review Accelerators and Beams
Volume	20
Numéro de publication	3
Les DOIs	https://doi.org/10.1103/PhysRevAccelBeams.20.032801
état	Publié - 2 mars 2017

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10.1103/PhysRevAccelBeams.20.032801

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Pommarel, L., Vauzour, B., Mégnin-Chanet, F., Bayart, E., Delmas, O., Goudjil, F., Nauraye, C., Letellier, V., Pouzoulet, F., Schillaci, F., Romano, F., Scuderi, V., Cirrone, G. A. P., Deutsch, E., Flacco, A., & Malka, V. (2017). Spectral and spatial shaping of a laser-produced ion beam for radiation-biology experiments. Physical Review Accelerators and Beams, 20(3), Article 032801. https://doi.org/10.1103/PhysRevAccelBeams.20.032801

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abstract = "The study of radiation biology on laser-based accelerators is most interesting due to the unique irradiation conditions they can produce, in terms of peak current and duration of the irradiation. In this paper we present the implementation of a beam transport system to transport and shape the proton beam generated by laser-target interaction for in vitro irradiation of biological samples. A set of four permanent magnet quadrupoles is used to transport and focus the beam, efficiently shaping the spectrum and providing a large and relatively uniform irradiation surface. Real time, absolutely calibrated, dosimetry is installed on the beam line, to enable shot-to-shot control of dose deposition in the irradiated volume. Preliminary results of cell sample irradiation are presented to validate the robustness of the full system.",

author = "L. Pommarel and B. Vauzour and F. M{\'e}gnin-Chanet and E. Bayart and O. Delmas and F. Goudjil and C. Nauraye and V. Letellier and F. Pouzoulet and F. Schillaci and F. Romano and V. Scuderi and Cirrone, {G. A.P.} and E. Deutsch and A. Flacco and V. Malka",

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Pommarel, L, Vauzour, B, Mégnin-Chanet, F, Bayart, E, Delmas, O, Goudjil, F, Nauraye, C, Letellier, V, Pouzoulet, F, Schillaci, F, Romano, F, Scuderi, V, Cirrone, GAP, Deutsch, E, Flacco, A & Malka, V 2017, 'Spectral and spatial shaping of a laser-produced ion beam for radiation-biology experiments', Physical Review Accelerators and Beams, VOL. 20, Numéro 3, 032801. https://doi.org/10.1103/PhysRevAccelBeams.20.032801

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T1 - Spectral and spatial shaping of a laser-produced ion beam for radiation-biology experiments

AU - Pommarel, L.

AU - Vauzour, B.

AU - Mégnin-Chanet, F.

AU - Bayart, E.

AU - Delmas, O.

AU - Goudjil, F.

AU - Nauraye, C.

AU - Letellier, V.

AU - Pouzoulet, F.

AU - Schillaci, F.

AU - Romano, F.

AU - Scuderi, V.

AU - Cirrone, G. A.P.

AU - Deutsch, E.

AU - Flacco, A.

AU - Malka, V.

PY - 2017/3/2

Y1 - 2017/3/2

N2 - The study of radiation biology on laser-based accelerators is most interesting due to the unique irradiation conditions they can produce, in terms of peak current and duration of the irradiation. In this paper we present the implementation of a beam transport system to transport and shape the proton beam generated by laser-target interaction for in vitro irradiation of biological samples. A set of four permanent magnet quadrupoles is used to transport and focus the beam, efficiently shaping the spectrum and providing a large and relatively uniform irradiation surface. Real time, absolutely calibrated, dosimetry is installed on the beam line, to enable shot-to-shot control of dose deposition in the irradiated volume. Preliminary results of cell sample irradiation are presented to validate the robustness of the full system.

AB - The study of radiation biology on laser-based accelerators is most interesting due to the unique irradiation conditions they can produce, in terms of peak current and duration of the irradiation. In this paper we present the implementation of a beam transport system to transport and shape the proton beam generated by laser-target interaction for in vitro irradiation of biological samples. A set of four permanent magnet quadrupoles is used to transport and focus the beam, efficiently shaping the spectrum and providing a large and relatively uniform irradiation surface. Real time, absolutely calibrated, dosimetry is installed on the beam line, to enable shot-to-shot control of dose deposition in the irradiated volume. Preliminary results of cell sample irradiation are presented to validate the robustness of the full system.

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