Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice

Francesca Castoldi; Guido Kroemer; Federico Pietrocola

doi:10.1080/2162402X.2022.2146855

Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice

Francesca Castoldi, Guido Kroemer, Federico Pietrocola

Résultats de recherche: Contribution à un journal › !!Comment/debate

3 Citations (Scopus)

Résumé

Writing in Science, Al Habsi et al. show that spermidine boosts the efficacy of monoclonal antibodies targeting PD-L1 in aged tumor-bearing mice by enhancing fatty acid oxidation in CD8 T cells. These results open new therapeutic avenues to improve the effectiveness of anticancer immunotherapies in aged patients.

langue originale	Anglais
Numéro d'article	2146855
journal	OncoImmunology
Volume	11
Numéro de publication	1
Les DOIs	https://doi.org/10.1080/2162402X.2022.2146855
état	Publié - 1 janv. 2022

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10.1080/2162402X.2022.2146855

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title = "Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice",

abstract = "Writing in Science, Al Habsi et al. show that spermidine boosts the efficacy of monoclonal antibodies targeting PD-L1 in aged tumor-bearing mice by enhancing fatty acid oxidation in CD8 T cells. These results open new therapeutic avenues to improve the effectiveness of anticancer immunotherapies in aged patients.",

keywords = "Aging, autophagy, immune checkpoints, mitochondria",

author = "Francesca Castoldi and Guido Kroemer and Federico Pietrocola",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.",

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AU - Castoldi, Francesca

AU - Kroemer, Guido

AU - Pietrocola, Federico

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KW - immune checkpoints

KW - mitochondria

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