TY - JOUR
T1 - Squamous cell carcinoma of the nasal columella
T2 - A retrospective study of 66 cases from the GETTEC
AU - Choussy, Olivier
AU - Babin, Emmanuel
AU - Temam, Stéphane
AU - Cosmidis, Alain
AU - Vedrine, Pierre Olivier
AU - De Raucourt, Dominique
AU - Sarini, Jérôme
AU - Bessede, Jean Pierre
AU - Lienhardt, Pierre Yves
AU - Dehesdin, Danièle
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Squamous cell carcinoma of the nasal columella (SCCNC) is a rare disease. We aimed to define a strategy for the diagnosis and management of nasal columella squamous cell carcinoma. Medical records of 66 patients presenting with columella squamous cell carcinoma in nine French hospitals, from 1980 to 2003, were evaluated to determine the clinical characteristics and current treatment of the disease. Mean age was 69 years. The sex ratio was one female for three males. Majority of the lesions were T1 N0 according to the classification international union against cancer. Patients underwent one of the three treatments: surgery alone for the T1 lesions, radiotherapy for tumors of T2-T3 and combined (surgery and radiotherapy) for T4 lesions. The 5-year Kaplan-Meier survival test was 39% and no difference was found between the therapeutic groups. Thirty-five (53%) tumor recurrences were observed with a median time of 43 months. As regards TNM classification and treatment, no significant difference between the two groups disease free/recurrence was found. Prognosis of early lesions was considered better than the advanced lesions. SCCNC is difficult to manage and has a poor prognosis. No therapeutic solution has yet been confirmed in the treatment of this pathology.
AB - Squamous cell carcinoma of the nasal columella (SCCNC) is a rare disease. We aimed to define a strategy for the diagnosis and management of nasal columella squamous cell carcinoma. Medical records of 66 patients presenting with columella squamous cell carcinoma in nine French hospitals, from 1980 to 2003, were evaluated to determine the clinical characteristics and current treatment of the disease. Mean age was 69 years. The sex ratio was one female for three males. Majority of the lesions were T1 N0 according to the classification international union against cancer. Patients underwent one of the three treatments: surgery alone for the T1 lesions, radiotherapy for tumors of T2-T3 and combined (surgery and radiotherapy) for T4 lesions. The 5-year Kaplan-Meier survival test was 39% and no difference was found between the therapeutic groups. Thirty-five (53%) tumor recurrences were observed with a median time of 43 months. As regards TNM classification and treatment, no significant difference between the two groups disease free/recurrence was found. Prognosis of early lesions was considered better than the advanced lesions. SCCNC is difficult to manage and has a poor prognosis. No therapeutic solution has yet been confirmed in the treatment of this pathology.
KW - Multicenter retrospective study
KW - Nasal columella
KW - Squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=36348944604&partnerID=8YFLogxK
U2 - 10.1007/s00405-007-0503-x
DO - 10.1007/s00405-007-0503-x
M3 - Review article
C2 - 17962969
AN - SCOPUS:36348944604
SN - 0937-4477
VL - 265
SP - 35
EP - 41
JO - European Archives of Oto-Rhino-Laryngology
JF - European Archives of Oto-Rhino-Laryngology
IS - 1
ER -