@article{9a58d02a57d74be3ac68f63e0e29cd75,
title = "STAT-1-independent upregulation of FADD and procaspase-3 and -8 in cancer cells treated with cytotoxic drugs",
abstract = "We have previously shown that treatment by anticancer drugs sensitized tumor cells to Fas (APO-1/ CD95)-mediated cell death. The present study demonstrates that the cytotoxic drugs cisplatin, doxorubicin and mitomycin C induce the accumulation of the Fas receptor, the FADD adaptor molecule, the procaspases-8, -3 and -2L and the proapoptotic molecule Bax in several human colon cancer cells. This upregulation is also observed in U3A myeloblastoma cells that do not express STAT-1, a transcription factor involved in the constitutive expression of procaspases. We conclude that anticancer drugs sensitize tumor cells to Fas-mediated cell death by a STAT-1-independent upregulation of molecules involved in this apoptotic pathway.",
keywords = "Anticancer drugs, Apoptosis, Caspases, FADD, FAS",
author = "Olivier Micheau and Arlette Hammann and Eric Solary and Dimanche-Boitrel, {Marie Th{\'e}r{\`e}se}",
note = "Funding Information: The authors are grateful to A. Fontana (Zurich University Hospital, Zurich, Switzerland) for Neuro-2A Fas-ligand transfected cells, X. Xu for U3A and U3A-STAT-1 cells (Rush Presbytarian St. Luke{\textquoteright}s Medical Center, Chicago, IL), and D.W. Nicholson (Merck Co, Toronto, Canada) for anti-human p17/19-caspase-3. This work was supported by grants from the Conseil R{\'e}gional de Bourgogne and the Bourgogne, Sa{\^o}ne et Loire, Ni{\`e}vre and National committees of the Ligue Nationale Contre le Cancer, and the Association pour la Recherche contre le Cancer (ARC# 9567). O. Micheau was supported by a grant from the Ligue Nationale Contre le Cancer (Sa{\^o}ne et Loire).",
year = "1999",
month = mar,
day = "24",
doi = "10.1006/bbrc.1999.0391",
language = "English",
volume = "256",
pages = "603--607",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
number = "3",
}