Stem cell replication, somatic mutations and role of randomness in the development of cancer

Vittorio Perduca; Ludmil B. Alexandrov; Michelle Kelly-Irving; Cyrille Delpierre; Hanane Omichessan; Mark P. Little; Paolo Vineis; Gianluca Severi

doi:10.1007/s10654-018-0477-6

Stem cell replication, somatic mutations and role of randomness in the development of cancer

Vittorio Perduca, Ludmil B. Alexandrov, Michelle Kelly-Irving, Cyrille Delpierre, Hanane Omichessan, Mark P. Little, Paolo Vineis, Gianluca Severi

Résultats de recherche: Contribution à un journal › Article 'review' › Revue par des pairs

11 Citations (Scopus)

Résumé

An intense scientific debate has recently taken place relating to the “bad luck” hypothesis in cancer development, namely that intrinsic random, and therefore unavoidable, mutagenic events would have a predominant role in tumorigenesis. In this article we review the main contributions to this debate and explain the reasons why the claim that cancer is mostly explained by intrinsic random factors is unsupported by data and theoretical models. In support of this, we present an analysis showing that smoking-induced mutations are more predictive of cancer risk than the lifetime number of stem cell cellular divisions.

langue originale	Anglais
Pages (de - à)	439-445
Nombre de pages	7
journal	European Journal of Epidemiology
Volume	34
Numéro de publication	5
Les DOIs	https://doi.org/10.1007/s10654-018-0477-6
état	Publié - 15 mai 2019
Modification externe	Oui

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10.1007/s10654-018-0477-6

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abstract = "An intense scientific debate has recently taken place relating to the “bad luck” hypothesis in cancer development, namely that intrinsic random, and therefore unavoidable, mutagenic events would have a predominant role in tumorigenesis. In this article we review the main contributions to this debate and explain the reasons why the claim that cancer is mostly explained by intrinsic random factors is unsupported by data and theoretical models. In support of this, we present an analysis showing that smoking-induced mutations are more predictive of cancer risk than the lifetime number of stem cell cellular divisions.",

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AU - Perduca, Vittorio

AU - Alexandrov, Ludmil B.

AU - Kelly-Irving, Michelle

AU - Delpierre, Cyrille

AU - Omichessan, Hanane

AU - Little, Mark P.

AU - Vineis, Paolo

AU - Severi, Gianluca

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AB - An intense scientific debate has recently taken place relating to the “bad luck” hypothesis in cancer development, namely that intrinsic random, and therefore unavoidable, mutagenic events would have a predominant role in tumorigenesis. In this article we review the main contributions to this debate and explain the reasons why the claim that cancer is mostly explained by intrinsic random factors is unsupported by data and theoretical models. In support of this, we present an analysis showing that smoking-induced mutations are more predictive of cancer risk than the lifetime number of stem cell cellular divisions.

KW - Cancer

KW - Environment

KW - Epidemiology

KW - Risk factors

KW - Somatic mutations

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