Streptozotocin, 1982-2022: Forty Years from the FDA's Approval to Treat Pancreatic Neuroendocrine Tumors

Jaume Capdevila, Michel Ducreux, Rocio García Carbonero, Enrique Grande, Thorvardur Halfdanarson, Marianne Pavel, Salvatore Tafuto, Staffan Welin, Vicente Valentí, Ramón Salazar

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    17 Citations (Scopus)

    Résumé

    In May 1982, the US Food and Drug Administration (FDA) approved the use of streptozotocin to treat pancreatic neuroendocrine tumors (panNETs). Thus, this year marks 40 years since that landmark date. This review of streptozotocin to treat panNETs is intended to commemorate this anniversary. A historical perspective of the chemical structure, pharmacokinetics, and mechanism of action of streptozotocin is followed by data from prospective and retrospective clinical studies. The last section of the review addresses the latest aspects and takes note of the prospects that lie ahead on the future horizon of the use of streptozotocin to treat panNETs, including ongoing clinical trials.

    langue originaleAnglais
    Pages (de - à)1155-1167
    Nombre de pages13
    journalNeuroendocrinology
    Volume112
    Numéro de publication12
    Les DOIs
    étatPublié - 1 nov. 2022

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