Subversion of calreticulin exposure as a strategy of immune escape

Guido Kroemer; Laurence Zitvogel

doi:10.1016/j.ccell.2021.01.014

Subversion of calreticulin exposure as a strategy of immune escape

Guido Kroemer, Laurence Zitvogel

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

10 Citations (Scopus)

Résumé

In this issue, Lin et al. report that, in malignant cells, stanniocalcin-1 (STC1) prevents the cell surface exposure of the “eat me” signal calreticulin, thereby avoiding phagocytosis by antigen-presenting cells. STC1 overexpression joins an arsenal of mechanisms through which tumor cells suppress calreticulin exposure and escape from immunosurveillance.

langue originale	Anglais
Pages (de - à)	449-451
Nombre de pages	3
journal	Cancer Cell
Volume	39
Numéro de publication	4
Les DOIs	https://doi.org/10.1016/j.ccell.2021.01.014
état	Publié - 12 avr. 2021

Accès au document

10.1016/j.ccell.2021.01.014

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title = "Subversion of calreticulin exposure as a strategy of immune escape",

abstract = "In this issue, Lin et al. report that, in malignant cells, stanniocalcin-1 (STC1) prevents the cell surface exposure of the “eat me” signal calreticulin, thereby avoiding phagocytosis by antigen-presenting cells. STC1 overexpression joins an arsenal of mechanisms through which tumor cells suppress calreticulin exposure and escape from immunosurveillance.",

author = "Guido Kroemer and Laurence Zitvogel",

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AU - Zitvogel, Laurence

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AB - In this issue, Lin et al. report that, in malignant cells, stanniocalcin-1 (STC1) prevents the cell surface exposure of the “eat me” signal calreticulin, thereby avoiding phagocytosis by antigen-presenting cells. STC1 overexpression joins an arsenal of mechanisms through which tumor cells suppress calreticulin exposure and escape from immunosurveillance.

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