Subversion of the chemotherapy-induced anticancer immune response by the ecto-ATPase CD39

Mickaël Michaud; Abdul Qader Sukkurwala; Isabelle Martins; Shensi Shen; Laurence Zitvogel; Guido Kroemer

doi:10.4161/onci.19070

Subversion of the chemotherapy-induced anticancer immune response by the ecto-ATPase CD39

Mickaël Michaud, Abdul Qader Sukkurwala, Isabelle Martins, Shensi Shen, Laurence Zitvogel, Guido Kroemer

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

53 Citations (Scopus)

Résumé

The efficacy of antineoplastic chemotherapies with anthracyclines or oxaliplatin relies on the induction of immunogenic cell death, thus provoking an anticancer immune response. Recently, we observed that overexpression of CD39, an ATPdegrading enzyme expressed on the cell surface, abolishes the immunogenicity of cell death, thus rendering cancers resistant against chemotherapy.

langue originale	Anglais
Pages (de - à)	393-395
Nombre de pages	3
journal	OncoImmunology
Volume	1
Numéro de publication	3
Les DOIs	https://doi.org/10.4161/onci.19070
état	Publié - 1 nov. 2012

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10.4161/onci.19070

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abstract = "The efficacy of antineoplastic chemotherapies with anthracyclines or oxaliplatin relies on the induction of immunogenic cell death, thus provoking an anticancer immune response. Recently, we observed that overexpression of CD39, an ATPdegrading enzyme expressed on the cell surface, abolishes the immunogenicity of cell death, thus rendering cancers resistant against chemotherapy.",

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AU - Martins, Isabelle

AU - Shen, Shensi

AU - Zitvogel, Laurence

AU - Kroemer, Guido

PY - 2012/11/1

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N2 - The efficacy of antineoplastic chemotherapies with anthracyclines or oxaliplatin relies on the induction of immunogenic cell death, thus provoking an anticancer immune response. Recently, we observed that overexpression of CD39, an ATPdegrading enzyme expressed on the cell surface, abolishes the immunogenicity of cell death, thus rendering cancers resistant against chemotherapy.

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KW - ATP release

KW - Anthracyclines

KW - Cancer

KW - Immunogenic cell death

KW - Macroautophagy

KW - Oxaliplatin

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