Survival and prognostic factors of primary liver cancer in Cotonou (Benin Republic) from 2014 to 2020

Titre traduit de la contribution: Survie et facteurs pronostiques du cancer primitif du foie à Cotonou (République du Bénin) de 2014 à 2020

Freddy Houéhanou Rodrigue Gnangnon, Aboudou Raïmi Kpossou, Koffi N’tcha, Salmane Ariyah Amidou, Vincent Zossou, Cosme Toume, Rodrigue S. Allodji, Dismand Stephan Houinato, Dansou Gaspard Gbessi, Jean Sehonou

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

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    Résumé

    Introduction. Primary liver cancer (PLC) occupied the 6th and 3rd place in the world respectively in terms of incidence and mortality in 2020. The objective of this work was to study the survival and prognostic factors of primary liver cancer from 2014 to 2020 in Cotonou. Materials and methods. This retrospective cohort study included 150 patients registered with primary liver cancer, in the database of the Cotonou Cancer Registry, over a seven-years period from 01/01/2014 to 12/31/2020. R 3.6.1 software was used for data analysis. The Kaplan-Meier method was used to estimate patient survival. The comparison of the survival curves was made by the Log-Rank test. The Cox proportional hazard model was established to identify predictors of mortality. The statistical significance threshold was set at 5%. Results. The mean age of the subjects was 51.7 ± 14.9 years and the sex-ratio 2.7. Half of the deaths occurred within the first 2 months after diagnosis. The prognostic factors, after multivariate analysis, were: age ≥ 60 (Hazard Ratio adjusted, HRa = 1.7; IC 95% [1.10-2.51]), alcohol consumption (HRa = 3.7; [1.33-9.42]), thera-peutic itinerary (HRa = 1. 9; [1.24-3.02]), hepatitis B virus infection (HRa = 7.7; [3.2612.29]), hepatitis C virus infection (HRa = 3.6; [1.38-9.43]) and time to consultation ≥4 weeks (HRa = 2.0; [1.01-4.05]). Conclusion. The mortality of patients with CPF in Cotonou is high with a median survival of 2 months. Factors, mostly modifiable, are associated with this mortality.

    Titre traduit de la contributionSurvie et facteurs pronostiques du cancer primitif du foie à Cotonou (République du Bénin) de 2014 à 2020
    langue originaleAnglais
    journalMedecine tropicale et sante internationale (MTSI)
    Volume4
    Numéro de publication3
    Les DOIs
    étatPublié - 1 janv. 2024

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