TY - JOUR
T1 - Survival and prognostic factors of primary liver cancer in Cotonou (Benin Republic) from 2014 to 2020
AU - Gnangnon, Freddy Houéhanou Rodrigue
AU - Kpossou, Aboudou Raïmi
AU - N’tcha, Koffi
AU - Amidou, Salmane Ariyah
AU - Zossou, Vincent
AU - Toume, Cosme
AU - Allodji, Rodrigue S.
AU - Houinato, Dismand Stephan
AU - Gbessi, Dansou Gaspard
AU - Sehonou, Jean
N1 - Publisher Copyright:
© 2024 SFMTSI.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - Introduction. Primary liver cancer (PLC) occupied the 6th and 3rd place in the world respectively in terms of incidence and mortality in 2020. The objective of this work was to study the survival and prognostic factors of primary liver cancer from 2014 to 2020 in Cotonou. Materials and methods. This retrospective cohort study included 150 patients registered with primary liver cancer, in the database of the Cotonou Cancer Registry, over a seven-years period from 01/01/2014 to 12/31/2020. R 3.6.1 software was used for data analysis. The Kaplan-Meier method was used to estimate patient survival. The comparison of the survival curves was made by the Log-Rank test. The Cox proportional hazard model was established to identify predictors of mortality. The statistical significance threshold was set at 5%. Results. The mean age of the subjects was 51.7 ± 14.9 years and the sex-ratio 2.7. Half of the deaths occurred within the first 2 months after diagnosis. The prognostic factors, after multivariate analysis, were: age ≥ 60 (Hazard Ratio adjusted, HRa = 1.7; IC 95% [1.10-2.51]), alcohol consumption (HRa = 3.7; [1.33-9.42]), thera-peutic itinerary (HRa = 1. 9; [1.24-3.02]), hepatitis B virus infection (HRa = 7.7; [3.2612.29]), hepatitis C virus infection (HRa = 3.6; [1.38-9.43]) and time to consultation ≥4 weeks (HRa = 2.0; [1.01-4.05]). Conclusion. The mortality of patients with CPF in Cotonou is high with a median survival of 2 months. Factors, mostly modifiable, are associated with this mortality.
AB - Introduction. Primary liver cancer (PLC) occupied the 6th and 3rd place in the world respectively in terms of incidence and mortality in 2020. The objective of this work was to study the survival and prognostic factors of primary liver cancer from 2014 to 2020 in Cotonou. Materials and methods. This retrospective cohort study included 150 patients registered with primary liver cancer, in the database of the Cotonou Cancer Registry, over a seven-years period from 01/01/2014 to 12/31/2020. R 3.6.1 software was used for data analysis. The Kaplan-Meier method was used to estimate patient survival. The comparison of the survival curves was made by the Log-Rank test. The Cox proportional hazard model was established to identify predictors of mortality. The statistical significance threshold was set at 5%. Results. The mean age of the subjects was 51.7 ± 14.9 years and the sex-ratio 2.7. Half of the deaths occurred within the first 2 months after diagnosis. The prognostic factors, after multivariate analysis, were: age ≥ 60 (Hazard Ratio adjusted, HRa = 1.7; IC 95% [1.10-2.51]), alcohol consumption (HRa = 3.7; [1.33-9.42]), thera-peutic itinerary (HRa = 1. 9; [1.24-3.02]), hepatitis B virus infection (HRa = 7.7; [3.2612.29]), hepatitis C virus infection (HRa = 3.6; [1.38-9.43]) and time to consultation ≥4 weeks (HRa = 2.0; [1.01-4.05]). Conclusion. The mortality of patients with CPF in Cotonou is high with a median survival of 2 months. Factors, mostly modifiable, are associated with this mortality.
KW - Benin
KW - Cotonou
KW - hepatitis B Virus
KW - Hepatitis C Virus
KW - Mortality
KW - Primary liver cancer
KW - Prognostic factors
KW - Sub-Saharan Africa
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=85202495988&partnerID=8YFLogxK
U2 - 10.48327/mtsi.v4i3.2024.418
DO - 10.48327/mtsi.v4i3.2024.418
M3 - Article
C2 - 39575094
AN - SCOPUS:85202495988
SN - 2778-2034
VL - 4
JO - Medecine tropicale et sante internationale (MTSI)
JF - Medecine tropicale et sante internationale (MTSI)
IS - 3
ER -