@article{323b74084eb24ac5abbafc283152c910,
title = "Synthesis and biological evaluation of two glycerolipidic prodrugs of didanosine for direct lymphatic delivery against HIV",
abstract = "Novel glycerolipidic prodrugs of didanosine and didanosine monophosphate designed to by-pass the hepatic first pass metabolism were synthesized and tested for their cytotoxicity and anti-HIV-1 activity. Formulation as liposomes of dipalmitoylphosphatidylcholine was elaborated. A simple quantitative HPLC-UV method was developed and validated, and ESI-MS was used for qualitative purpose. These two prodrugs exhibited promising biological activities against HIV-1 in in vitro infected cell culture.",
keywords = "Anti-HIV nucleoside, Bioavailability, Enzyme inhibitors, Lipid-nucleoside conjugate, Prodrugs",
author = "Muriel Lalanne and Angelo Paci and Karine Andrieux and Nathalie Dereuddre-Bosquet and Pascal Clayette and Alain Deroussent and Micheline R{\'e} and Gilles Vassal and Patrick Couvreur and Didier Desma{\"e}le",
note = "Funding Information: The financial support of the {\textquoteleft}Agence Nationale de la Recherche{\textquoteright} (ANR, Grant NT05-1_43236 SYLIANNU) is acknowledged. The authors thank MENRT for providing financial support to ML. ",
year = "2007",
month = apr,
day = "15",
doi = "10.1016/j.bmcl.2007.01.062",
language = "English",
volume = "17",
pages = "2237--2240",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
number = "8",
}