TY - JOUR
T1 - Systemic therapies for salivary gland carcinoma (excluding adenoid cystic carcinoma)
T2 - REFCOR recommendations by the formal consensus method
AU - Sarradin, V.
AU - Digue, L.
AU - Vergez, S.
AU - Thariat, J.
AU - Fakhry, N.
AU - Chabrillac, E.
AU - Bensadoun, R. J.
AU - Ferrand, F. R.
AU - Even, C.
N1 - Publisher Copyright:
© 2023 Elsevier Masson SAS
PY - 2024/9/1
Y1 - 2024/9/1
N2 - Objective: To determine the therapeutic indications for systemic medical treatment in the management of salivary gland carcinoma (excluding adenoid cystic carcinoma) according to the clinical situation. Materials and methods: The French Network of Rare Head and Neck Tumors (REFCOR) formed a steering group who drafted a narrative review of the literature published on Medline and proposed recommendations. The level of adherence to the recommendations was then assessed by a rating group, according to the formal consensus method. Results: Salivary gland carcinoma is rare and there is currently insufficient evidence to indicate chemotherapy at the localized stage. At the metastatic stage, initial management can be based on a phase of monitoring for indolent disease. Some histological subtypes (salivary duct carcinoma and adenocarcinoma) are more aggressive and require systemic treatment from the outset. To guide systemic treatment, it is recommended to perform immunohistochemistry and molecular biology analyses (overexpression of HER2 and androgen receptors, NTRK fusion, next-generation sequencing). Conclusion: Salivary gland carcinoma is a rare tumor for which there are currently few effective medical treatments. It is therefore recommended to include patients in clinical trials.
AB - Objective: To determine the therapeutic indications for systemic medical treatment in the management of salivary gland carcinoma (excluding adenoid cystic carcinoma) according to the clinical situation. Materials and methods: The French Network of Rare Head and Neck Tumors (REFCOR) formed a steering group who drafted a narrative review of the literature published on Medline and proposed recommendations. The level of adherence to the recommendations was then assessed by a rating group, according to the formal consensus method. Results: Salivary gland carcinoma is rare and there is currently insufficient evidence to indicate chemotherapy at the localized stage. At the metastatic stage, initial management can be based on a phase of monitoring for indolent disease. Some histological subtypes (salivary duct carcinoma and adenocarcinoma) are more aggressive and require systemic treatment from the outset. To guide systemic treatment, it is recommended to perform immunohistochemistry and molecular biology analyses (overexpression of HER2 and androgen receptors, NTRK fusion, next-generation sequencing). Conclusion: Salivary gland carcinoma is a rare tumor for which there are currently few effective medical treatments. It is therefore recommended to include patients in clinical trials.
KW - Chemotherapy
KW - Locally advanced disease
KW - Metastatic disease
KW - Salivary gland cancer
KW - Systemic therapy
UR - http://www.scopus.com/inward/record.url?scp=85178168949&partnerID=8YFLogxK
U2 - 10.1016/j.anorl.2023.11.004
DO - 10.1016/j.anorl.2023.11.004
M3 - Article
C2 - 38040592
AN - SCOPUS:85178168949
SN - 1879-7296
VL - 141
SP - 280
EP - 285
JO - European Annals of Otorhinolaryngology, Head and Neck Diseases
JF - European Annals of Otorhinolaryngology, Head and Neck Diseases
IS - 5
ER -