Tailed giant Tupanvirus possesses the most complete translational apparatus of the known virosphere

Jônatas Abrahão; Lorena Silva; Ludmila Santos Silva; Jacques Yaacoub Bou Khalil; Rodrigo Rodrigues; Thalita Arantes; Felipe Assis; Paulo Boratto; Miguel Andrade; Erna Geessien Kroon; Bergmann Ribeiro; Ivan Bergier; Herve Seligmann; Eric Ghigo; Philippe Colson; Anthony Levasseur; Guido Kroemer; Didier Raoult; Bernard La Scola

doi:10.1038/s41467-018-03168-1

Tailed giant Tupanvirus possesses the most complete translational apparatus of the known virosphere

Jônatas Abrahão, Lorena Silva, Ludmila Santos Silva, Jacques Yaacoub Bou Khalil, Rodrigo Rodrigues, Thalita Arantes, Felipe Assis, Paulo Boratto, Miguel Andrade, Erna Geessien Kroon, Bergmann Ribeiro, Ivan Bergier, Herve Seligmann, Eric Ghigo, Philippe Colson, Anthony Levasseur, Guido Kroemer, Didier Raoult, Bernard La Scola

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

189 Citations (Scopus)

Résumé

Here we report the discovery of two Tupanvirus strains, the longest tailed Mimiviridae members isolated in amoebae. Their genomes are 1.44-1.51 Mb linear double-strand DNA coding for 1276-1425 predicted proteins. Tupanviruses share the same ancestors with mimivirus lineages and these giant viruses present the largest translational apparatus within the known virosphere, with up to 70 tRNA, 20 aaRS, 11 factors for all translation steps, and factors related to tRNA/mRNA maturation and ribosome protein modification. Moreover, two sequences with significant similarity to intronic regions of 18 S rRNA genes are encoded by the tupanviruses and highly expressed. In this translation-associated gene set, only the ribosome is lacking. At high multiplicity of infections, tupanvirus is also cytotoxic and causes a severe shutdown of ribosomal RNA and a progressive degradation of the nucleus in host and non-host cells. The analysis of tupanviruses constitutes a new step toward understanding the evolution of giant viruses.

langue originale	Anglais
Numéro d'article	749
journal	Nature Communications
Volume	9
Numéro de publication	1
Les DOIs	https://doi.org/10.1038/s41467-018-03168-1
état	Publié - 1 déc. 2018

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10.1038/s41467-018-03168-1

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Abrahão, J., Silva, L., Silva, L. S., Khalil, J. Y. B., Rodrigues, R., Arantes, T., Assis, F., Boratto, P., Andrade, M., Kroon, E. G., Ribeiro, B., Bergier, I., Seligmann, H., Ghigo, E., Colson, P., Levasseur, A., Kroemer, G., Raoult, D., & La Scola, B. (2018). Tailed giant Tupanvirus possesses the most complete translational apparatus of the known virosphere. Nature Communications, 9(1), Article 749. https://doi.org/10.1038/s41467-018-03168-1

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title = "Tailed giant Tupanvirus possesses the most complete translational apparatus of the known virosphere",

abstract = "Here we report the discovery of two Tupanvirus strains, the longest tailed Mimiviridae members isolated in amoebae. Their genomes are 1.44-1.51 Mb linear double-strand DNA coding for 1276-1425 predicted proteins. Tupanviruses share the same ancestors with mimivirus lineages and these giant viruses present the largest translational apparatus within the known virosphere, with up to 70 tRNA, 20 aaRS, 11 factors for all translation steps, and factors related to tRNA/mRNA maturation and ribosome protein modification. Moreover, two sequences with significant similarity to intronic regions of 18 S rRNA genes are encoded by the tupanviruses and highly expressed. In this translation-associated gene set, only the ribosome is lacking. At high multiplicity of infections, tupanvirus is also cytotoxic and causes a severe shutdown of ribosomal RNA and a progressive degradation of the nucleus in host and non-host cells. The analysis of tupanviruses constitutes a new step toward understanding the evolution of giant viruses.",

author = "J{\^o}natas Abrah{\~a}o and Lorena Silva and Silva, {Ludmila Santos} and Khalil, {Jacques Yaacoub Bou} and Rodrigo Rodrigues and Thalita Arantes and Felipe Assis and Paulo Boratto and Miguel Andrade and Kroon, {Erna Geessien} and Bergmann Ribeiro and Ivan Bergier and Herve Seligmann and Eric Ghigo and Philippe Colson and Anthony Levasseur and Guido Kroemer and Didier Raoult and {La Scola}, Bernard",

note = "Publisher Copyright: {\textcopyright} 2018 The Author(s).",

year = "2018",

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doi = "10.1038/s41467-018-03168-1",

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Abrahão, J, Silva, L, Silva, LS, Khalil, JYB, Rodrigues, R, Arantes, T, Assis, F, Boratto, P, Andrade, M, Kroon, EG, Ribeiro, B, Bergier, I, Seligmann, H, Ghigo, E, Colson, P, Levasseur, A, Kroemer, G, Raoult, D & La Scola, B 2018, 'Tailed giant Tupanvirus possesses the most complete translational apparatus of the known virosphere', Nature Communications, VOL. 9, Numéro 1, 749. https://doi.org/10.1038/s41467-018-03168-1

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AU - Abrahão, Jônatas

AU - Silva, Lorena

AU - Silva, Ludmila Santos

AU - Khalil, Jacques Yaacoub Bou

AU - Rodrigues, Rodrigo

AU - Arantes, Thalita

AU - Assis, Felipe

AU - Boratto, Paulo

AU - Andrade, Miguel

AU - Kroon, Erna Geessien

AU - Ribeiro, Bergmann

AU - Bergier, Ivan

AU - Seligmann, Herve

AU - Ghigo, Eric

AU - Colson, Philippe

AU - Levasseur, Anthony

AU - Kroemer, Guido

AU - Raoult, Didier

AU - La Scola, Bernard

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AB - Here we report the discovery of two Tupanvirus strains, the longest tailed Mimiviridae members isolated in amoebae. Their genomes are 1.44-1.51 Mb linear double-strand DNA coding for 1276-1425 predicted proteins. Tupanviruses share the same ancestors with mimivirus lineages and these giant viruses present the largest translational apparatus within the known virosphere, with up to 70 tRNA, 20 aaRS, 11 factors for all translation steps, and factors related to tRNA/mRNA maturation and ribosome protein modification. Moreover, two sequences with significant similarity to intronic regions of 18 S rRNA genes are encoded by the tupanviruses and highly expressed. In this translation-associated gene set, only the ribosome is lacking. At high multiplicity of infections, tupanvirus is also cytotoxic and causes a severe shutdown of ribosomal RNA and a progressive degradation of the nucleus in host and non-host cells. The analysis of tupanviruses constitutes a new step toward understanding the evolution of giant viruses.

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